Application of LncRNA in serum as marker for URSA (unexplained recurrent spontaneous abortion) diagnosis and pregnancy outcome evaluation

A marker and outcome technology, applied in the field of biomedicine, can solve problems such as low diagnostic efficiency, achieve high diagnostic accuracy, meet testing needs, and facilitate testing.

Active Publication Date: 2018-10-26
SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE +1
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  • Abstract
  • Description
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Problems solved by technology

Although there are reports on the application of LncRNAs in the auxiliary diagnosis and treatment of recurrent miscarriage, their diagnostic efficiency is low.

Method used

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  • Application of LncRNA in serum as marker for URSA (unexplained recurrent spontaneous abortion) diagnosis and pregnancy outcome evaluation
  • Application of LncRNA in serum as marker for URSA (unexplained recurrent spontaneous abortion) diagnosis and pregnancy outcome evaluation
  • Application of LncRNA in serum as marker for URSA (unexplained recurrent spontaneous abortion) diagnosis and pregnancy outcome evaluation

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Embodiment Construction

[0031] It should be noted that the following detailed description is exemplary and intended to provide further explanation of the present invention. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.

[0032] It should be noted that the terminology used here is only for describing specific embodiments, and is not intended to limit exemplary embodiments according to the present invention. As used herein, unless the context clearly dictates otherwise, the singular is intended to include the plural, and it should also be understood that when the terms "comprising" and / or "comprising" are used in this specification, they mean There are features, steps, operations and / or combinations thereof.

[0033] Explanation of terms:

[0034] LncRNA ENST00000514235: long-chain non-coding ribonucleic acid LncRNA ENST00000514235, the nucleic acid sequence of wh...

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Abstract

The invention discloses application of LncRNA ENST00000514235 in serum as a marker for URSA (unexplained recurrent spontaneous abortion) diagnosis and pregnancy outcome evaluation. A corresponding detection kit is developed by taking the LncRNA ENST00000514235 as the marker for URSA diagnosis and pregnancy outcome evaluation. The detection kit has the advantages of high detection sensitivity, highspecificity, convenience in detection and capability of meeting diagnosis detection requirements of patients suffering from URSA, and clinical verification shows that the diagnosis accuracy rate is high.

Description

technical field [0001] The invention belongs to the field of biomedicine, and specifically relates to the application of LncRNAENST00000514235 in serum as a marker for the diagnosis of unexplained recurrent spontaneous abortion (URSA) and pregnancy outcome assessment. Background technique [0002] Spontaneous abortion occurs twice or more in a row, which is called recurrent spontaneous abortion (RSA). The incidence rate is about 1% to 5% of women of childbearing age. The etiology is complex, except for a few chromosomes, endocrine, anatomy, infection and other factors. In addition, about 80% of the cause is unknown, known as unexplained recurrent spontaneous abortion (unexplained recurrentspontaneous abortion, URSA). URSA seriously endangers the reproductive health of women of childbearing age, but currently there is a lack of biological indicators with strong specificity, high sensitivity, and good stability. There is no clear and unified standard for clinical intervention ...

Claims

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Application Information

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IPC IPC(8): C12Q1/6883C12N15/113
CPCC12Q1/6883C12Q2600/136C12Q2600/158C12Q2600/178
Inventor 李霞王彬赵霖张华魏然尹训强张云虹张振郭强朱肖肖
Owner SHANDONG UNIV OF TRADITIONAL CHINESE MEDICINE
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