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Microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors

A bioactive factor, bovine pericardium technology, used in tissue regeneration, medical science, prosthesis, etc., can solve the problems of difficult endogenous growth of cells, poor remodeling effect, etc., to reduce residual toxicity, preserve three-dimensional structure and biological Mechanical properties, the effect of reducing the concentration of use

Inactive Publication Date: 2018-10-12
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although ionic detergents can achieve a good decellularization effect, the residual toxicity, easy removal of soluble bioactive factors, and dense matrix material structure make it difficult for cells to grow endogenously, and the remodeling effect in the host is not good. Bottlenecks that limit its processing of clinical tissue specimens

Method used

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  • Microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors
  • Microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors
  • Microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors

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Embodiment Construction

[0019] In order to make the technical means, creative features, goals and effects of the present invention easy to understand, the following examples will specifically illustrate the microporous acellular bovine pericardial matrix capable of slow-releasing bioactive factors of the present invention in conjunction with the accompanying drawings.

[0020] figure 1 It is a schematic diagram of the bovine pericardium and the microporous decellularized bovine pericardium matrix capable of slow-releasing bioactive factors in the embodiment of the present invention.

[0021] figure 2 It is a scanning electron microscope schematic diagram of the bovine pericardium and the microporous decellularized bovine pericardium matrix capable of slow-releasing bioactive factors in the embodiment of the present invention.

[0022] like figure 1 , 2 as shown, figure 1 (a) Bovine pericardium before processing, figure 2 (a) Bovine pericardium representing normal control, figure 1 (b), figu...

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Abstract

The invention provides microporous decellularized bovine pericardium matrix capable of slow release of bio-active factors. The matrix is characterized in that the microporous decellularized bovine pericardium matrix capable of slow release of the bio-active factors has a microporous structure and the bio-active factors adhering to the surface of the microporous structure,the microporous structureis spongy,microporous of the microporous structure is circular or elliptical,the microporous decellularized bovine pericardium matrix capable of slow release of the bio-active factors has different microporous sizes,and the largest diameter is up to 50 micrometers,wherein the bio-active factors are growth factors with biological activity; according to the microporous decellularized bovine pericardium matrix capable of slow release of the bioactive factors,bovine pericardium is placed in a non-ionic detergent buffer under a vacuum condition,and after multiple freeze thawing is conducted,the bovine pericardium is vibrated and washed in the non-ionic detergent buffer,sterile deionized water and a phosphate solution in turn,and finally is immersed in a bio-active factor agarose material to obtain the matrix.

Description

Technical field [0001] The invention relates to the field of tissue engineering, and in particular to a microporous acellular bovine pericardial matrix that can sustainably release bioactive factors. Background technique [0002] Tissue engineering is the inoculation of living cells on a tissue matrix to create a biomaterial that is compatible with the recipient's tissue, non-immunogenic, does not require anticoagulation, and is highly durable. Among them, natural matrix materials are one of the important contents of tissue engineering research. An ideal natural matrix material should have the following advantages: (1) good tissue compatibility and no biological toxicity; (2) have a three-dimensional structure, and the material must be porous and sponge-like, which is conducive to cell adhesion and infiltration and the absorption of nutrients. Deep penetration and excretion of metabolites; (3) Rich in bioactive factors, providing a good microenvironment for host cell growth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/36A61L27/50A61L27/54A61L27/56
CPCA61L27/3633A61L27/3687A61L27/3691A61L27/507A61L27/54A61L27/56A61L2300/414A61L2430/20A61L2430/40
Inventor 刘晓红吴昊徐志云夏翠萍
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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