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Leech anticoagulation active substance extracting process and extraction process optimizing method

A technology of active substance and extraction process, which is applied in the field of extraction process and optimized extraction process of leech anticoagulant active substance, can solve the problem of high content obtained by orthogonal design method, and achieve the effect of simple and easy to understand model

Inactive Publication Date: 2018-10-09
ZHEJIANG CHINESE MEDICAL UNIVERSITY
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Problems solved by technology

And in comparison with ordinary orthogonal experiments, the yield of the orthogonal design method is not as high as that obtained by the response surface method

Method used

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  • Leech anticoagulation active substance extracting process and extraction process optimizing method
  • Leech anticoagulation active substance extracting process and extraction process optimizing method
  • Leech anticoagulation active substance extracting process and extraction process optimizing method

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Embodiment Construction

[0039] The present invention will be specifically introduced below in conjunction with the accompanying drawings and specific embodiments.

[0040] A process for extracting leech anticoagulant active substances, comprising: weighing leech powder, adding physiological saline, fully shaking and then leaching, shaking from time to time during the leaching process, centrifuging, taking the supernatant and putting it in a test tube, and the extraction is completed; The extraction conditions are as follows: the leaching time is 165 minutes, the solid-liquid ratio is 8 times, and the extraction temperature is 70° C.; the solid-liquid ratio is the ratio of leech powder to normal saline.

[0041] This conclusion is obtained from the following experiments;

[0042] The main instruments and software used in the experiment are: FA2104N electronic balance (Shanghai Jinghai Instrument Co., Ltd.); BS323S electronic balance (Beijing Sartorius Instrument System Co., Ltd.); 3K15 desktop high-sp...

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Abstract

The invention discloses a leech anticoagulation active substance extracting process and an extraction process optimizing method. The leech anticoagulation active substance extracting process comprisesthe following steps: weighing leech powder, adding physiological saline, fully shaking and leaching, shaking from time to time during leaching, centrifuging and placing a supernatant in a test tube,thereby completing extraction, wherein the extraction conditions are that the leaching time is 165 minutes, the solid-liquid ratio is 8 times and the extraction temperature is 70 DEG C, and the solid-liquid ratio is the ratio of leech powder to physiological saline. In the R language environment, a neural network is combined with a genetic algorithm to optimize the leech anticoagulation active substance extracting process and carry out target optimization according to a test result of central composite design in a response surface method, so as to lay the foundation for the research on extraction of active substances of traditional Chinese medicine leech.

Description

technical field [0001] The invention relates to the field of extraction technology, in particular to an extraction technology of leech anticoagulant active substances and a method for optimizing the extraction technology. Background technique [0002] Cardiovascular and cerebrovascular disease is a disease that seriously threatens human health and life. Modern life rhythm is irregular, coronary heart disease, heart failure, arrhythmia, diabetic cardiomyopathy, etc. occur frequently, especially in middle-aged and elderly people over 50 years old. The morbidity rate is high and the mortality rate is high. In my country, there are about 230 million patients suffering from risk factors of potential cardiovascular diseases. Especially the curative effect of western medicine can not prevent and treat well at present, and the development of traditional Chinese medicine cardiovascular and cerebrovascular drugs is urgent. [0003] The leeches recorded in the 2015 edition of the "Chin...

Claims

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Application Information

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IPC IPC(8): A61K35/62A61P7/02A61P9/10A61P9/12A61P17/00A61P35/00G06N3/04G06N3/08
CPCA61P7/02A61P9/10A61P9/12A61P17/00A61P35/00G06N3/086A61K35/62G06N3/044
Inventor 张宇燕周静李敏金伟锋
Owner ZHEJIANG CHINESE MEDICAL UNIVERSITY
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