Hypertensive disorders in pregnancy associated marker composition and application thereof
A technology of gestational hypertension and composition, which is applied in the application of gestational hypertension-related marker composition, risk assessment and diagnosis, the field of clinical early prediction of gestational hypertension, and can solve the lack of biomarkers, etc. question
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Embodiment 1
[0046] Samples: 100 control serum samples from healthy pregnant women, 100 serum samples from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks of pregnancy serum samples, during this time period, all patients did not show symptoms of hypertensive disorders in pregnancy symptoms, but later in pregnancy, both develop hypertensive disorder of pregnancy);
[0047] Detection method: 200 samples of the above-mentioned serum samples were detected with a protein chip, which included Clusterin, SH3domain-binding glutamic acid-rich-like protein 3, relaxin-3, Cytokeratin 18, SERPIN A5, Reagents for Pregnancy-specific beta-1-glycoprotein 4, SERPIN C1, APOC4 and Annexin A1 marker concentrations. Then, cluster analysis, factor analysis, principal component analysis, and COX regression analysis were performed on the test results to obtain prediction and condition monitoring equations to evaluate the risk of hypertension in pregnant women in the future.
Embodiment 2
[0049] Samples: 100 control plasma samples from healthy pregnant women, 100 plasma samples from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks after pregnancy, during this time period, all patients did not show symptoms of hypertensive disorders in pregnancy symptoms, but later in pregnancy, both develop hypertensive disorder of pregnancy);
[0050] Method: 200 samples of the above sample plasma were tested with a kit, which included Calnexin, Clusterin, relaxin-3, Attractin, SERPIN A4, SERPIN C1, Insulin-likegrowth factor-bindingprotein 2 and Annexin in the subject’s sample plasma. The calculation method of the reagent with the A1 marker concentration is the same as that in Example 1, and the risk of high blood pressure in a pregnant woman in the subsequent pregnancy is evaluated.
Embodiment 3
[0052] Samples: 100 samples of control blood from healthy pregnant women, 100 samples of blood from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks after pregnancy, during this time period, all patients did not show symptoms of hypertensive disorders in pregnancy symptoms, but later in pregnancy, both develop hypertensive disorder of pregnancy);
[0053] Method: 200 samples of the above-mentioned blood samples were tested with test strips, which included markers capable of detecting Clusterin, relaxin-3, Attractin, SERPIN C1, Insulin-like growth factor-binding protein 2 and Annexin A1 in the blood of subjects Concentration of antibodies, the calculation method is the same as in Example 1, and the risk of high blood pressure in pregnant women in the future pregnancy process is evaluated.
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