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Hypertensive disorders in pregnancy associated marker composition and application thereof

A technology of gestational hypertension and composition, which is applied in the application of gestational hypertension-related marker composition, risk assessment and diagnosis, the field of clinical early prediction of gestational hypertension, and can solve the lack of biomarkers, etc. question

Active Publication Date: 2018-10-02
GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the early diagnosis of hypertension in pregnancy has not yet an effective program, the main reason is the lack of effective biomarkers

Method used

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  • Hypertensive disorders in pregnancy associated marker composition and application thereof
  • Hypertensive disorders in pregnancy associated marker composition and application thereof
  • Hypertensive disorders in pregnancy associated marker composition and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Samples: 100 control serum samples from healthy pregnant women, 100 serum samples from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks of pregnancy serum samples, during this time period, all patients did not show symptoms of hypertensive disorders in pregnancy symptoms, but later in pregnancy, both develop hypertensive disorder of pregnancy);

[0047] Detection method: 200 samples of the above-mentioned serum samples were detected with a protein chip, which included Clusterin, SH3domain-binding glutamic acid-rich-like protein 3, relaxin-3, Cytokeratin 18, SERPIN A5, Reagents for Pregnancy-specific beta-1-glycoprotein 4, SERPIN C1, APOC4 and Annexin A1 marker concentrations. Then, cluster analysis, factor analysis, principal component analysis, and COX regression analysis were performed on the test results to obtain prediction and condition monitoring equations to evaluate the risk of hypertension in pregnant women in the future.

Embodiment 2

[0049] Samples: 100 control plasma samples from healthy pregnant women, 100 plasma samples from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks after pregnancy, during this time period, all patients did not show symptoms of hypertensive disorders in pregnancy symptoms, but later in pregnancy, both develop hypertensive disorder of pregnancy);

[0050] Method: 200 samples of the above sample plasma were tested with a kit, which included Calnexin, Clusterin, relaxin-3, Attractin, SERPIN A4, SERPIN C1, Insulin-likegrowth factor-bindingprotein 2 and Annexin in the subject’s sample plasma. The calculation method of the reagent with the A1 marker concentration is the same as that in Example 1, and the risk of high blood pressure in a pregnant woman in the subsequent pregnancy is evaluated.

Embodiment 3

[0052] Samples: 100 samples of control blood from healthy pregnant women, 100 samples of blood from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks after pregnancy, during this time period, all patients did not show symptoms of hypertensive disorders in pregnancy symptoms, but later in pregnancy, both develop hypertensive disorder of pregnancy);

[0053] Method: 200 samples of the above-mentioned blood samples were tested with test strips, which included markers capable of detecting Clusterin, relaxin-3, Attractin, SERPIN C1, Insulin-like growth factor-binding protein 2 and Annexin A1 in the blood of subjects Concentration of antibodies, the calculation method is the same as in Example 1, and the risk of high blood pressure in pregnant women in the future pregnancy process is evaluated.

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Abstract

The invention provides a reagent capable of detecting a hypertensive disorders in pregnancy associated marker composition. The marker composition comprises three or more of calnexin, attractin, clusterin, cytokeratin 18, pregnancy-specific beta-1-glycoprotein 4, SH3 domain-binding glutamic acid-rich-like protein 3, serine protease inhibitor A4, plasma serine protease inhibitor A5, serpin peptidaseinhibitor, clade C member 1, relaxin-3, APOC4, Annexin A1, and insulin-like growth factor-binding protein 2. The marker composition provided by the invention has gestational hypertension detection accuracy up to 90% or more meets the requirements of clinical disease screening, which are unachievable by the current gestational hypertension detection technology.

Description

technical field [0001] The present invention relates to markers related to hypertension, in particular to a composition of markers related to hypertensive disorder in pregnancy and its application in early prediction, risk assessment and diagnosis of hypertensive disorder in clinical pregnancy. Background technique [0002] Hypertensive disorders in pregnancy (HDP) is a common disease during pregnancy, often associated with obstetrical hemorrhage, convulsions, and premature delivery, and is the main cause of maternal and perinatal death. According to the current international classification, hypertensive disorders of pregnancy include: gestational hypertension, preeclampsia-eclampsia, chronic hypertension with superimposed preeclampsia, etc. According to a domestic survey of 3.7 million people, the average incidence of PIH is 9.2%, and the etiology is still unknown. [0003] The current clinical detection techniques for hypertensive disorders in pregnancy mainly include: ...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/689G01N2333/471G01N2800/321G01N2800/368
Inventor 段天雄
Owner GUANGZHOU WOMEN AND CHILDRENS MEDICAL CENTER
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