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Marker composition capable of detecting gestational hypertension associated diseases and application thereof

A technology of gestational hypertension and a composition, which is applied in risk assessment and diagnosis, early prediction of clinical gestational hypertension, and the field of gestational hypertension-related marker compositions, which can solve the lack of biomarkers, etc. question

Inactive Publication Date: 2018-11-23
段天雄
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Therefore, the early diagnosis of hypertension in pregnancy has not yet an effective program, the main reason is the lack of effective biomarkers

Method used

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  • Marker composition capable of detecting gestational hypertension associated diseases and application thereof
  • Marker composition capable of detecting gestational hypertension associated diseases and application thereof
  • Marker composition capable of detecting gestational hypertension associated diseases and application thereof

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Embodiment Construction

[0042] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be described in further detail below in conjunction with the accompanying drawings and examples, but the scope of protection claimed by the present invention is not limited to the examples.

[0043] The present invention performs a paired t-test on the experimental data, and uses the P value of the paired t-test (threshold <0.05) to determine differentially expressed metabolites. Threshold (P-value): A statistical quantity that represents the significance of a result. P value <0.05 means that the probability of random error producing this result is less than 0.05.

[0044] Samples: 100 control serum samples from healthy pregnant women, 100 serum samples from gestational hypertensive patients matched for gestational age (preferably 12-20 weeks of pregnancy serum samples, during this time period, all patients did not show symptoms of hypertensive dis...

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Abstract

The invention provides a reagent of a marker composition capable of detecting gestational hypertension associated diseases. The marker composition is prepared from glutamate-rich SH3 domain binding protein 3, plasma protease inhibitory protein C1, relaxin, serine protease inhibitory protein A5, clusterin, serine protease inhibitory protein A4, serine protease peptidase inhibitory protein C1, phosphatidylinositol-glycan biosynthesis type F protein, pregnancy-associated plasma protein, insulin-like growth factors, calnexin and attractin. The accuracy rate of the marker composition provided by the invention for detecting gestational hypertension is 98% which meets the requirement for clinical disease screening and can not be realized by the existing gestational hypertension detection technology.

Description

technical field [0001] The present invention relates to markers related to hypertension, in particular to a composition of markers related to hypertensive disorder in pregnancy and its application in early prediction, risk assessment and diagnosis of hypertensive disorder in clinical pregnancy. Background technique [0002] Hypertensive disorders in pregnancy (HDP) is a common pregnancy disease, often associated with obstetric hemorrhage, convulsions, premature delivery and other problems in clinical practice, and is the main cause of maternal and perinatal death. According to the current international classification, hypertensive disorders during pregnancy include: gestational hypertension, preeclampsia-eclampsia, chronic hypertension with superimposed preeclampsia, etc. According to a domestic survey of 3.7 million people, the average incidence of PIH is 9.2%, and the etiology is still unknown. [0003] The current clinical detection techniques for hypertensive disorders ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/68
CPCG01N33/689G01N2333/471G01N2800/321G01N2800/368
Inventor 段天雄
Owner 段天雄
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