Application of soybean peptide in preparing medicine for controlling airway inflammatory reaction

A technology of airway inflammation and soybean peptide, which is applied in the field of soybean peptide in the preparation of drugs for the prevention and treatment of airway inflammation. It can solve the problems that soybean peptide has not been reported, and achieve the effect of improving pathological damage and reducing airway inflammation

Inactive Publication Date: 2018-09-14
河南省南街村(集团)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Soybean peptide (soybean peptide, SP), also known as soybean protein hydrolyzed peptide, contains 8 kinds of essential amino acid components required by the human body. 500Da to 3000Da, it has the effects of regulating immunity, promoting muscle growth, anti-tumor, and lowering blood lipids, but there is no report on whether soybean peptide has other effects

Method used

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  • Application of soybean peptide in preparing medicine for controlling airway inflammatory reaction
  • Application of soybean peptide in preparing medicine for controlling airway inflammatory reaction
  • Application of soybean peptide in preparing medicine for controlling airway inflammatory reaction

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Embodiment Construction

[0015] The present invention will be further described below in conjunction with some specific examples.

[0016] 1 Materials and methods

[0017] 1.1 Experimental animals

[0018] SD rats (SPF grade), male, 8 weeks old, weighing 180-200g, were adaptively fed in the animal room for 5 days, 4-5 per cage, and the litter was changed every 3-4 days, and the indoor temperature was adjusted to 22 ± 2°C, humidity 45%-65%, 12h light and dark photoperiod, regular feeding, free drinking water.

[0019] 1.2 Main reagents

[0020] Soybean peptide, pentobarbital sodium ovalbumin, aluminum hydroxide, rabbit anti-Notch 1, Jagged 1, Hes 1, NF-κB and β-actin antibodies, goat anti-rabbit horseradish peroxidase (horseradish peroxidase, HRP ) labeled secondary antibody, enhanced RIPA protein lysate, BCA protein concentration determination kit, color pre-stained protein molecular weight standard (10-180KDa), PVDF membrane and SDS-PAGE gel preparation kit, Trizol total RNA extraction reagent, E...

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Abstract

The invention discloses application of soybean peptide in preparing medicine for controlling an airway inflammatory reaction. The soybean peptide can obviously reduce airway inflammation in asthmaticrats and relieve lung and bronchial tissue pathological damage and has a certain control effect on bronchial asthma, and a soybean peptide anti-inflammatory and asthma-relieving mechanism is related to down-regulated Notch 1, Jagged 1, Hes 1 and NF-kappa B signal channels. Accordingly, it is found that the soybean peptide can serve as position medicine controlling airway inflammation.

Description

technical field [0001] The invention belongs to the field of biotechnology, and in particular relates to the use of a soybean peptide in the preparation of medicines for preventing and treating airway inflammation. Background technique [0002] Soybean peptide (soybean peptide, SP), also known as soybean protein hydrolyzed peptide, contains 8 kinds of essential amino acid components required by the human body. 500Da to 3000Da, it has the effects of regulating immunity, promoting muscle growth, anti-tumor, and lowering blood lipids, but there is no report on whether soybean peptide has other effects. [0003] Bronchial asthma (BA), referred to as "asthma", is a common inflammatory disease of the respiratory system, in which various inflammatory factors or mediators are involved, often accompanied by macrophages, eosinophils, mast cells, lymphocytes, etc. Inflammatory cell infiltration such as neutrophils and airway epithelial cell damage lead to airway smooth muscle spasm an...

Claims

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Application Information

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IPC IPC(8): A61K38/01A61P11/06A61P29/00
CPCA61K38/011A61P11/06A61P29/00
Inventor 马永超金少举徐松涛李盘欣黄亚男史咏华王培英彭丽李晓玲
Owner 河南省南街村(集团)有限公司
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