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Application of Mdivi-1 in preparation of corneal alkali burn therapeutic drugs

A technology of 1.mdivi-1 and alkali burn, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of poor curative effect of visual impairment and achieve the effect of reducing ROS generation

Active Publication Date: 2018-09-07
NANCHANG UNIV
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  • Abstract
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  • Claims
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AI Technical Summary

Problems solved by technology

These drug treatments can only slightly alleviate the condition, and have poor curative effect on the inflammatory reaction and visual impairment caused by corneal alkali burns

Method used

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  • Application of Mdivi-1 in preparation of corneal alkali burn therapeutic drugs
  • Application of Mdivi-1 in preparation of corneal alkali burn therapeutic drugs
  • Application of Mdivi-1 in preparation of corneal alkali burn therapeutic drugs

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Experimental program
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Embodiment Construction

[0015] The present invention will be described in further detail below in conjunction with the embodiments and with reference to the accompanying drawings.

[0016] In order to better understand the essence of the present invention, the use of Mdivi-1 will be demonstrated with animal experiments and results below.

[0017] 1. Materials and methods

[0018] 1. Animals

[0019] In this experiment, healthy 6-8 week old C57BL / 6 experimental mice were selected. Male and female were randomly selected. They were purchased from Hunan Changsha Slake Kingda Co., Ltd., approved by the Shanghai Experimental Animal Center of the Chinese Academy of Sciences, and raised in the special animal room of the Institute of Ophthalmology, Nanchang University. The feeding and experimental procedures of all experimental animals were strictly in accordance with the terms of protection of experimental animals. The environment in the animal room is quiet, the room temperature is about 25°C, and the lig...

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Abstract

The invention relates to application of Mdivi-1 in preparation of corneal alkali burn therapeutic drugs. The animal experiment proves the effectiveness of the Mdivi-1 in treating the corneal alkali burn. The material inhibits chondriokinesis through inhibiting the DRP1 and Dnm1, ROS production, inflammatory factor IL-1 beta and IL-6 and TNF-alpha expression levels are reduced, corneal neovascularization is reduced, and accordingly, the corneal injury and the visual impairment caused by the corneal alkali burn are improved.

Description

technical field [0001] The present invention relates to the invention field of medicine application, and relates to the application of corneal alkali burn medicine. Background technique [0002] Mdivi-1 (chemical formula: C 15 h 10 C l2 N 2 o 2 S, molecular weight: 353.22, chemical structure as shown in the figure below), is a white or khaki solid, easily soluble in DMSO, insoluble or poorly soluble in H 2 O. [0003] [0004] Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial fission dynamin-related GTPase (DRP1) and mitochondrial fission Dynamin I (Dnm1). In scientific research, the main use of Mdivi-1 has two aspects: [0005] In vitro experiments, treatment of cells with Mdivi-1 inhibited mitochondrial outer membrane permeabilization resulting in decreased release of cytochrome C and inhibited cell apoptosis. [0006] In vitro and in vivo experiments, Mdivi-1 was applied to anti-stroke and neuroprotection. [0007] At present, there is a lack of ...

Claims

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Application Information

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IPC IPC(8): A61K31/517A61P27/02
CPCA61K31/517A61P27/02
Inventor 韩小建张坤郭苗钰徐丹闫单单
Owner NANCHANG UNIV
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