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Method and apparatus for determining proton treatment dosage and range by using proton induced thermoacoustic signals

An acoustic signal, proton technology, applied in the field of medical physics, can solve the problems of unusable, unknown velocity model of acoustic wave propagation, etc., to achieve scientific results and solve the effect of double coupling of position and velocity

Active Publication Date: 2018-09-04
WUHAN UNIV
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Problems solved by technology

However, water is a homogeneous medium, and the propagation speed of sound waves in water is known, while the human body medium is inhomogeneous, and the speed model of sound waves propagating in the human body is unknown, so the method of the KC Jones team cannot be used in actual proton therapy used in

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  • Method and apparatus for determining proton treatment dosage and range by using proton induced thermoacoustic signals
  • Method and apparatus for determining proton treatment dosage and range by using proton induced thermoacoustic signals

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Embodiment Construction

[0031] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0032] In order to solve the problem of positioning the Bragg peak in the process of proton therapy for tumors, the propagation speed of the unknown thermoacoustic signal in the human body. The invention discloses a method and equipment for determining the dosage and range of proton therapy by proton-induced thermoacoustic signals. Proton energy distribution range and therapeutic dose in the body. In this invention, it is necessary to use sensors placed at intervals along the proton irradiation direction close to the body surface of the human body to receive the thermoacoustic signal induced by th...

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Abstract

The invention discloses a method and a device for determining the proton treatment dosage and range by using proton induced thermoacoustic signals. The method includes: receiving a proton induced thermoacoustic signal through an ultrasonic sensor, and analyzing the proton induced thermoacoustic signal and extracting the travel time and waveform information; performing ray tracing on a propagationpath of the proton induced thermoacoustic signal in a body, and calculating the minimum travel time of a first arrival wave; using the perturbation method to determine a partial derivative matrix of the travel time to a position of a thermal sound source, and establishing an inversion equation; obtaining the position of the thermal sound source and a velocity model through iterative fitting; solving the problem of double coupling of thermal sound source position disturbance and velocity model disturbance by using the parameter separation method; further correcting the position of thermal soundsource and the velocity model that the proton induced thermoacoustic signal is propagated in human body through the disturbance; and determining the dosage and the range of proton treatment through aproton beam energy distribution relationship. The experimental results obtained by the invention not only save the running time but also ensure the positioning accuracy; and the method and the devicecan be widely applied in proton treatment.

Description

technical field [0001] The present invention relates to the field of medical physics, in particular to a method and equipment for determining the dose and range of proton therapy through proton-induced thermoacoustic signals. Background technique [0002] For a long time, tumors have seriously threatened people's health. At present, radiation therapy is one of the commonly used methods to control and treat tumors, but in the process of clinical radiation therapy, as the radiation enters the human body, the dose and the depth of the radiation decay exponentially, which makes the normal tissues or organs before and after the tumor Suffer varying degrees of impact, resulting in radiation reactions and damage. Proton therapy for tumors can effectively improve this situation, because the physical characteristics of the Bragg (Bragg) peak are formed during proton beam irradiation, so that a large amount of energy is deposited at the position of the Bragg peak and quickly deposite...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61N5/10
Inventor 张东彭浩何施琦熊高文杨艳
Owner WUHAN UNIV
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