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Porous calcium phosphate/natural polymer composite scaffold, preparation method and application thereof

A technology of natural polymer and porous calcium phosphate, applied in the field of porous calcium phosphate/natural polymer composite scaffold and its preparation, to achieve the effect of simple and fast preparation process, promotion of adhesion and proliferation, and promotion of adhesion

Inactive Publication Date: 2018-09-04
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In order to overcome the shortcoming of preparing porous calcium phosphate support material at present, the primary purpose of the present invention is to provide a kind of porous calcium phosphate / natural polymer composite support

Method used

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  • Porous calcium phosphate/natural polymer composite scaffold, preparation method and application thereof
  • Porous calcium phosphate/natural polymer composite scaffold, preparation method and application thereof
  • Porous calcium phosphate/natural polymer composite scaffold, preparation method and application thereof

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Experimental program
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Effect test

Embodiment 1

[0045] PCL (Mn=45000) was selected as the sacrificial model material, gelatin was selected as a natural polymer, and the bone cement system was "tetracalcium phosphate + calcium hydrogen phosphate (molar ratio 1:1)". The implementation steps included:

[0046] (1) Use 3D-Bioplotter TM The printer prefabricated the PCL cylindrical sacrificial model: put the PCL into the high-temperature barrel, select a needle with an inner diameter of 300 μm, and set the heating temperature to 180°C. Use AutoCAD software to design a cylinder model with a diameter of 8 mm and a height of 5 mm, and import it into the Bioplotter RP layering software for layering processing. The layering height is 240 μm, and then import the layered file into the Visual Machines software to set the internal fiber stacking of the model The method is 0° and 90° alternately, and the fiber spacing is 1 mm. After holding for 20 minutes, adjust the platform temperature to 4°C, nitrogen extrusion pressure to 1.6 bar, fi...

Embodiment 2

[0052] PCL (Mn=45000) was selected as the sacrificial model material, gelatin was selected as the natural polymer, and the bone cement system was "partial crystalline calcium phosphate + calcium hydrogen phosphate + hydroxyapatite (mass ratio 45:45:10)". The implementation steps included :

[0053] (1) Use 3D-Bioplotter TM The printer prefabricated the PCL cylindrical sacrificial model: put the PCL into the high-temperature barrel, select a needle with an inner diameter of 300 μm, and set the heating temperature to 180°C. Use AutoCAD software to design a cylinder model with a diameter of 8 mm and a height of 5 mm, and import it into the Bioplotter RP layering software for layering processing. The layering height is 240 μm, and then import the layered file into the Visual Machines software to set the internal fiber stacking of the model The method is 0° and 90° alternately, and the fiber spacing is 1mm. After 20 minutes of heat preservation, adjust the platform temperature to...

Embodiment 3

[0059] TPU (Mn=60000) was selected as the sacrificial model material, gelatin was selected as a natural polymer, and the bone cement system was "tetracalcium phosphate + calcium hydrogen phosphate (molar ratio 1:1)". The implementation steps included:

[0060] (1) Use 3D-Bioplotter TM The printer prefabricated the TPU cylindrical sacrificial model: put the TPU into the high-temperature barrel, select a needle with an inner diameter of 300 μm, and set the heating temperature to 220°C. Use AutoCAD software to design a cylinder model with a diameter of 8 mm and a height of 5 mm, and import it into the Bioplotter RP layering software for layering processing. The layering height is 240 μm, and then import the layered file into the Visual Machines software to set the internal fiber stacking of the model The method is 0° and 90° alternately, and the fiber spacing is 1mm. After 20 minutes of heat preservation, adjust the platform temperature to 20°C, nitrogen extrusion pressure to 2....

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Abstract

The invention discloses a porous calcium phosphate / natural polymer composite scaffold, a preparation method and application thereof. The method comprises the following steps: firstly utilizing 3D printing to manufacture a polymer support in which holes are completely connected as a sacrifice model, putting the sacrifice model into a mold, then uniformly mixing natural polymer microspheres with calcium phosphate bone cement to prepare a slurry, pouring the slurry into the model so that the holes of the model are filled with the slurry, then using a solvent to remove the polymer model so as to obtain the connected porous calcium phosphate / natural polymer composite scaffold. Combined with the characteristics of bone cement such as low-temperature self-setting and good mechanical property andthe characteristics of natural polymer such as high biological activity and easy degradation, the three-dimensional connected macroporous structure composite scaffold is prepared. After the scaffold is planted into the body, the natural polymer microspheres are rapidly degraded so as to form a hierarchical pore structure in situ. High-temperature processing is not needed in the preparation process, the biological activity and mechanical property are good, the structure and degradation rate are controllable, the ingrowth of bone tissues and blood vessels is facilitated, and the bone repair effect is improved.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing bone damage, and in particular relates to a porous calcium phosphate / natural polymer composite scaffold and its preparation method and application. Background technique [0002] As the largest tissue and organ of the human body, the bone plays a very important role, but it is easy to cause bone defects due to various reasons. In modern society, there are countless patients with bone defects caused by trauma, aging, inflammation, tumors, and congenital malformations, but clinically there is still no effective means for repairing bone defects, especially large bone defects. Although bone has the function of self-healing, large bone defects cannot be completely repaired by the body alone. In this case, external intervention and auxiliary treatment are required for repair. Currently clinically used external interventions include autologous bone grafting, xenograft bone grafting, and imp...

Claims

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Application Information

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IPC IPC(8): A61L27/56A61L27/58A61L27/50A61L27/46
CPCA61L27/46A61L27/50A61L27/56A61L27/58A61L2400/08A61L2430/02C08L89/00
Inventor 叶建东范培榕钱国文
Owner SOUTH CHINA UNIV OF TECH
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