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A system to determine short-term prognosis in patients with cirrhosis and hepatorenal syndrome

A technology for syndrome and liver cirrhosis, applied in the field of medicine, can solve problems such as the lack of short-term prognosis judgment methods for patients with liver cirrhosis and hepatorenal syndrome, and achieve the effect of prolonging survival time

Active Publication Date: 2020-05-05
BEIJING DITAN HOSPITAL CAPITAL MEDICAL UNIV
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Problems solved by technology

However, there is still a lack of a more effective method for judging the short-term prognosis of patients with liver cirrhosis and hepatorenal syndrome in my country

Method used

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  • A system to determine short-term prognosis in patients with cirrhosis and hepatorenal syndrome
  • A system to determine short-term prognosis in patients with cirrhosis and hepatorenal syndrome
  • A system to determine short-term prognosis in patients with cirrhosis and hepatorenal syndrome

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Embodiment 1

[0027]A retrospective collection of 362 patients with liver cirrhosis and hepatorenal syndrome diagnosed for the first time from January 2013 to December 2014, 62 cases of primary kidney disease were excluded, 52 cases of incomplete clinical data, and finally 246 patients were eligible for inclusion standard. 196 patients with hepatorenal syndrome were used for modeling, of which 130 survived and 66 died; 50 patients with hepatorenal syndrome were used for verification, of which 12 survived and 38 died. Inclusion criteria for hepatorenal syndrome: HRS was diagnosed and typed according to the definition and diagnostic criteria of HRS published by the International Ascites Research Group in 2007. 1) Liver cirrhosis with ascites; 2) Serum creatinine > 133 μmol / L; 3) Diuretics stopped for at least 2 days and the serum creatinine value did not improve after volume expansion with albumin (recommended albumin infusion dose 1g / kg, up to 100g / d, the improvement of serum creatinine sho...

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Abstract

The invention discloses a system of determining short-term prognosis of hepatic cirrhosis and hepatorenal syndrome patients. The system of determining short-term prognosis of hepatic cirrhosis and hepatorenal syndrome patients includes an input device, a computing device and an output device, wherein the computing device includes a memory and a processor; a computer program is saved in the memory;the processor is configured to execute the computer program saved in the memory so as to realize the algorithm of a discrimination function; and the discrimination function returns the short-term prognosis of hepatorenal syndrome patients to be tested through liver cancer history, creatinine (Cr), neutrophilic granulocyte percentage (NE%) and glutamic-pyruvic transaminase (ALT). The system of determining short-term prognosis of hepatic cirrhosis and hepatorenal syndrome patients performs analysis and comparison by means of the current easily obtained clinic lab test index, establishes a survival prognosis scoring model for hepatic cirrhosis and hepatorenal syndrome patients, and guides the patients to further complete the related treatment to prolong the survival time of the patients.

Description

technical field [0001] The present disclosure relates to the field of medicine, in particular, to a system for determining the short-term prognosis of patients with liver cirrhosis and hepatorenal syndrome. Background technique [0002] Hepatorenal syndrome (HRS) in cirrhosis is functional renal failure on the basis of severe liver disease. Its typical clinical manifestations are spontaneous oliguria or anuria, azotemia, dilutional hyponatremia, and hyponatruria. Liver cirrhosis and hepatorenal syndrome are clinically divided into type Ⅰ and type Ⅱ. In type Ⅰ HRS, the blood creatinine rises more than 2 times within 2 weeks, reaching or exceeding 226 μmol / L. In type Ⅱ HRS, the blood creatinine rises between 133 and 226 μmol / L. between. Type Ⅲ HRS is a severe disease with rapid progression and a median survival time of 2 weeks; type Ⅱ HRS progresses relatively slowly with relatively mild liver and kidney damage and a median survival time of 6 months. Regardless of type Ⅰ HR...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G16H50/20
CPCG16H50/20
Inventor 杨志云张栓刘晓利王宪波江宇泳杨玉英于浩
Owner BEIJING DITAN HOSPITAL CAPITAL MEDICAL UNIV
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