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Method for removing ginkgolic acid from folium ginkgo and application thereof

A technology of ginkgo biloba and ginkgolic acid is applied in the field of plant active ingredient extraction, which can solve the problem of high ginkgolic acid content, achieve the effects of improving quality, inhibiting the dissolution of ginkgolic acid, and ensuring extraction efficiency

Inactive Publication Date: 2018-08-17
XUZHOU UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the technical problem to be solved by the present invention is to provide a method for removing ginkgolic acid in ginkgo leaves, so as to solve the problem of excessive ginkgolic acid content in ginkgo leaf extracts in the prior art

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0027] The method for removing ginkgolic acid in ginkgo leaves described in this embodiment specifically includes: get 1 kg of dried ginkgo leaves, add to 12 kg of alanine tetrafluoride boron salt [AlaBF 4 ], at 45 ° C temperature for 2h dipping pretreatment, followed by solid-liquid separation and conventional washing to remove the solvent, the resulting ginkgo leaves were collected, and vacuum-dried, that is.

Embodiment 2

[0029] The method for removing ginkgolic acid in ginkgo leaves described in this embodiment specifically includes: get 1 kg of dried ginkgo leaves, add to 15 kg of alanine tetrafluoride boron salt [AlaBF 4 ], at 40 ℃ temperature for 2h dipping pretreatment, followed by solid-liquid separation and conventional washing to remove the solvent, collect the obtained Ginkgo biloba leaves, and vacuum-dried, that is.

Embodiment 3

[0031] The method for removing ginkgolic acid in ginkgo leaves described in this embodiment specifically includes: get 1 kg of dried ginkgo leaves, add to 10 kg of alanine boron tetrafluoride [AlaBF 4 ], at 50 ° C temperature for 2 hours of dipping pretreatment, followed by solid-liquid separation and conventional washing to remove the solvent, the resulting ginkgo leaves were collected, and vacuum-dried to obtain that.

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PUM

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Abstract

The invention belongs to the technical field of extraction of plant effective ingredients, and particularly relates to a method for removing ginkgolic acid from folium ginkgo and application thereof.The method for removing ginkgolic acid from folium ginkgo comprises the steps that selected amino acid ionic liquid is taken as a pre-treatment solvent to conduct dipping pre-treatment on folium ginkgo, dissolution of ginkgolic acid from folium ginkgo is effectively inhibited, the content of ginkgolic acid in a follow-up folium ginkgo extract is reduced, dissolution of the by-product ginkgolic acid is effectively inhibited, the quality of a target product is further improved, the technology of toxicity attenuation in the following process is simplified, and the extraction efficiency of foliumginkgo polysaccharide and folium ginkgo flavones is ensured while the content of ginkgolic acid is effectively reduced.

Description

technical field [0001] The invention belongs to the technical field of extraction of effective plant components, and in particular relates to a method for removing ginkgolic acid from ginkgo leaves and an application thereof. Background technique [0002] Ginkgo tree is an ancient tree species, known as a "living fossil" plant, a magical medical tree, and a precious tree species unique to my country. When the Jurassic dinosaurs took over the earth more than 250 million years ago, ginkgo was already one of the most prosperous plants. Life on earth has gone through hundreds of billions of years of changes, especially after being covered by glaciers in the fourth century, only ginkgo still maintains its most primitive appearance, and is called a "living fossil" in the history of biological evolution. Its leaves, fruits, and seeds all have high medicinal value, its pharmacological effects are constantly being recognized, and the scope of clinical application is gradually expand...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16
CPCA61K36/16A61K2236/10A61K2236/331A61K2236/53
Inventor 刘恩岐张建萍高兆建陈尚龙巫永华
Owner XUZHOU UNIV OF TECH
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