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Porphyrin nano-material as well as preparation method and application thereof to preparation of medicine for near-infrared photothermal therapy

A nanomaterial, porphyrin technology, applied in the field of material chemistry and biology, can solve the problem of weak absorption of porphyrin nanomaterials, and achieve the effect of low equipment requirements, high photothermal performance, and simple synthesis process

Inactive Publication Date: 2018-08-14
HENAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, existing studies have shown that the absorption peak of porphyrin can be extended to the visible region (wavelength of ultraviolet light: below 400nm, wavelength of visible light: 400-760nm, infrared light: greater than 760nm) by self-assembly method. Near-infrared absorption is weak

Method used

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  • Porphyrin nano-material as well as preparation method and application thereof to preparation of medicine for near-infrared photothermal therapy
  • Porphyrin nano-material as well as preparation method and application thereof to preparation of medicine for near-infrared photothermal therapy
  • Porphyrin nano-material as well as preparation method and application thereof to preparation of medicine for near-infrared photothermal therapy

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preparation example Construction

[0033] The invention provides a kind of preparation method of porphyrin nanometer material, comprises the following steps:

[0034] Mix the anionic emulsifier with protic acid and water to obtain an acidic solution of the anionic emulsifier;

[0035] Mixing the porphyrin precursor with a polar solvent to obtain a porphyrin precursor solution;

[0036] The obtained porphyrin precursor solution is mixed with an anionic emulsifier acidic solution, and a self-assembly reaction occurs to obtain a porphyrin nanometer material.

[0037] In the invention, the anionic emulsifier is mixed with protonic acid and water to obtain an acidic solution of the anionic emulsifier. In the present invention, the protonic acid is preferably an inorganic protonic acid or an organic protonic acid. In the present invention, the inorganic protic acid is preferably hydrochloric acid or perchloric acid. In the present invention, the concentration of the inorganic protonic acid is preferably 0.3M. In ...

Embodiment 1

[0056] (1) Dissolve SDBS (99.99% purity) in water to prepare 0.01M SDBS solution;

[0057] (2) Add standard 1M hydrochloric acid solution dropwise into SDBS solution to prepare SDBS aqueous solutions with different pH values, pH values ​​are 6.66, 3.90, 3.56, 3.21, 2.87, 2.71.

[0058] (3) Dissolving TAPP in DMF to make a DMF solution of 0.01M TAPP;

[0059] (4) Inject 0.5mL of the solution prepared in step (3) into 9.5mL of the solution of different pH values ​​prepared in step (2), stir at 25°C for 48h, centrifuge at 13000rpm for 30min, pour off the supernatant, collect the precipitate, and obtain Porphyrin nanomaterials.

[0060] The UV-vis spectra of porphyrin nanomaterials obtained at different pH values ​​are as follows: figure 1 shown by figure 1 It can be seen that when the pH value of the SDBS solution is lower than 3.50, the porphyrin nanomaterial has an absorption peak with strong absorption in the near-infrared region in the Q band. Depend on figure 1 It can b...

Embodiment 2

[0063] Change the kind of protonic acid in embodiment 1, comprises the following steps:

[0064] (1) Dissolve SDBS (99.99% purity) in water to prepare 0.01M SDBS solution;

[0065] (2) Different protonic acids (formic acid, acetic acid, propionic acid, p-toluenesulfonic acid, lactic acid) were added dropwise to (1) to prepare an SDBS aqueous solution with a pH value of 2.71.

[0066] (3) Anilinoporphyrin is dissolved in DMF to make a DMF solution of 0.01M anilinoporphyrin;

[0067] (4) Quickly inject 0.5mL of the solution prepared in step (3) into 9.5mL of the solution in step (2), stir at 25°C for 48h, centrifuge at 13000r for 30min, pour off the supernatant, collect the precipitate, and obtain the porphyrin nanomaterial .

[0068] The absorption of porphyrin nanoparticles obtained after doping with different protonic acids is summarized, such as Image 6 As shown, it can be seen that the absorption of porphyrin nanoparticles obtained by different protonic acids is in the ...

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Abstract

The invention provides a preparation method of a porphyrin nano-material and belongs to the field of material chemistry and biology. The porphyrin nano-material prepared by adopting a protonic acid doped co-solvent method has the advantages of small size, strong near-infrared absorption and very high photothermal performance. According to the preparation method provided by the invention, the adding amount of protonic acid is regulated and controlled so that the protonation degree of a porphyrin precursor is regulated and controlled, and furthermore, controllable preparation of an assembling body composed of a nano short rod, a nano-wire and nanoparticles can be regulated and controlled; good dissolution performance of a polar solvent on the porphyrin precursor is combined and a settling-out speed of the porphyrin precursor in a poor solvent is alleviated by utilizing an anion emulsifier; the adding amount of the protonic acid is adjusted so that the weak mutual action force between molecules of the porphyrin precursor is adjusted, and near-infrared absorption of the self-assembling body of the porphyrin precursor is realized.

Description

technical field [0001] The invention relates to the technical fields of material chemistry and biology, in particular to a porphyrin nanometer material, a preparation method thereof and an application in the preparation of near-infrared photothermal therapy drugs. Background technique [0002] With the development of economy and society, the problems of environmental pollution and unhealthy diet are becoming more and more prominent, and the incidence of cancer worldwide is showing a continuous growth trend. The incidence of cancer in China accounts for 21.8% of the global incidence of cancer. number one killer. "Cancer" is the full name of all malignant tumors, and it is a kind of disease caused by the abnormal mechanism of controlling cell proliferation. How to effectively prevent and treat cancer is a major challenge that mankind is currently facing, and it is also a problem that needs to be solved urgently. [0003] In recent decades, people have done a lot of research ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00
Inventor 白锋王静菡钟永王杰菲王孝胡姚情
Owner HENAN UNIVERSITY
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