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Adsorbent and preparation method for removing medium and macromolecular toxins from the body of uremia patients

An adsorbent and macromolecular technology, applied in the field of biomedicine, can solve the problems of poor selectivity, large pressure drop, poor mechanical strength, etc., and achieve the effect of excellent adsorption capacity

Active Publication Date: 2020-09-15
山东卓逸医疗科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the selectivity of activated carbon adsorbents and chitosan cross-linked resins is poor, the mechanical strength is poor, it is easily broken, the pressure drop is large, and it is not easy to operate. The resin may enter the blood during the perfusion process, thereby causing serious consequences such as coagulation and platelet adhesion.

Method used

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  • Adsorbent and preparation method for removing medium and macromolecular toxins from the body of uremia patients
  • Adsorbent and preparation method for removing medium and macromolecular toxins from the body of uremia patients
  • Adsorbent and preparation method for removing medium and macromolecular toxins from the body of uremia patients

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] (1) Preparation of carrier microspheres

[0028]15.4g of styrene and 84.6g of divinylbenzene were added to a 1000mL beaker, and then 327.3g of toluene, 109.1g of ethyl acetate, 43.6g of gasoline and 6.96g of benzoyl peroxide were added to it, and stirred to dissolve. After complete dissolution, mix well to obtain an organic phase. At room temperature, add 11.02 g of polyvinyl alcohol and 580 mL of deionized water to a 2000 mL three-necked flask to prepare a 1.9% (mass fraction) aqueous solution of polyvinyl alcohol, and heat and stir to 45° C. to fully dissolve the polyvinyl alcohol to obtain Water phase, stop stirring, add the obtained uniformly mixed organic phase into the water phase, start the stirrer, adjust the stirring rate to make the droplets evenly distributed, after the temperature is raised to 50°C, the temperature is raised to 80°C at 5°C / 10min. , make the droplet shape, and keep it at this temperature for 3h after it is set, then slowly heat up to 95°C at...

Embodiment 2

[0034] (1) Preparation of carrier microspheres

[0035] Add 30g of styrene and 120g of divinylbenzene to a 1000mL beaker, then add 189.5g of toluene, 63.2g of ethyl acetate, 47.3g of gasoline and 4.5g of benzoyl peroxide to it, stir to dissolve it, and wait until it is completely dissolved. After that, it was thoroughly mixed to obtain an organic phase. At room temperature, add 9 g of polyvinyl alcohol and 900 mL of deionized water to a 2000 mL three-necked flask to prepare a 1% (mass fraction) aqueous solution of polyvinyl alcohol, and heat and stir to 45 ° C to fully dissolve the polyvinyl alcohol to obtain water. phase, stop stirring, add the obtained organic phase mixed uniformly into the water phase, start the stirrer, adjust the stirring rate to make the droplets evenly distributed, after the temperature is raised to 46 °C, and then heated to 75 °C at 4 °C / 10min, Make the droplet shape, continue to hold at this temperature for 4h after the shape is set, then slowly heat...

Embodiment 3

[0041] (1) Preparation of carrier microspheres

[0042] Add 28.6g of styrene and 71.4g of divinylbenzene to a 1000mL beaker, then add 120g of toluene, 30g of ethyl acetate, 30g of gasoline and 2g of benzoyl peroxide, stir to dissolve, and after the dissolution is complete, Mix well to obtain an organic phase. At room temperature, add 7.5 g of polyvinyl alcohol and 450 mL of deionized water to a 2000 mL three-necked flask to prepare a 1.5% (mass fraction) aqueous solution of polyvinyl alcohol, and heat and stir to 45° C. to fully dissolve the polyvinyl alcohol to obtain Water phase, stop stirring, add the obtained uniformly mixed organic phase to the water phase, start the stirrer, adjust the stirring rate to make the droplets evenly distributed, after the temperature is raised to 42°C, the temperature is raised to 70°C at 3°C / 10min. , make the droplet shape, and keep it at this temperature for 3.5h after it is set, then slowly heat up to 94°C at a rate of 1°C / 5min, react for ...

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Abstract

The invention relates to an adsorbent used for clearing middle and macro molecule toxin in body of uremia patients and a preparation method thereof. According to the molecule size of middle and macromolecules such as beta2-MG, PTH, AGEs, Hcy and IL-6 and performance characteristics thereof, a functional adsorbent which can efficiently clear main middle and macro molecule toxins such as beta2-MG,PTH, AGEs, Hcy and IL-6 in the blood of the uremia patients is prepared by taking a mesoporous polystyrene hydrophobic resin as a carrier, which undergoes chloromethylation activation, and then performing chemical crosslinking grafting of vinylamine; and the adsorbent has large adsorption capacity, good mechanical strength, good biocompatibility and high adsorption selectivity. The adsorbent is used for treating uremia by blood perfusion, can take the advantages of blood filtering mainly for clearing micromolecular toxin, and provides a new method for treating uremia by combination of hematodialysis and blood perfusion.

Description

Technical field: [0001] The invention belongs to the technical field of biomedicine. Specifically, it relates to a novel medical adsorbent, especially an adsorbent suitable for blood perfusion to remove medium and macromolecular toxins in uremia patients and a preparation method thereof. [0002] technical background: [0003] Uremia is a series of complex clinical syndromes caused by the progressive and irreversible decline of renal function caused by various renal diseases in the body, which eventually leads to the loss of renal function, which makes the metabolic wastes in the body unable to be discharged in time and accumulate in large quantities. Uremia may lead to complications such as water, electrolyte and acid-base metabolism disorders, cardiovascular disease, nervous system disease, respiratory system disease, gastrointestinal disease, and skin itching, which seriously affects the physical and mental health and life safety of patients. At present, it is known that ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J20/26B01J20/28B01J20/30A61M1/36
CPCA61M1/3687A61M2202/0413B01J20/265B01J20/28021A61M2202/0021
Inventor 欧来良柴雅敏王为超
Owner 山东卓逸医疗科技股份有限公司
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