Nutritional compositions and infant formulas to promote myelination in the brain
A nutritional composition and composition technology, applied in the direction of medical preparations containing active ingredients, drug combinations, food ingredients, etc., can solve the problem of not providing myelin formation track
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[0200] For the sake of clarity, all embodiments and aspects reported below shall apply mutatis mutandis to the different embodiments and aspects described for the invention.
[0201] All indicated amounts for nutritional substances are expressed per dry weight of the nutritional composition, unless otherwise indicated.
[0202] Where the nutrient may be included in the composition in different forms (either by itself or in the form of a salt, complex or more complex structure comprising the nutrient), the amounts reported below shall be intended to refer to the nutrient itself. quantity.
[0203] The nutritional composition according to the invention comprises fatty acid derivatives or mixtures thereof.
[0204] It may be particularly advantageous if the composition according to the invention also comprises one or more of the following ingredients: vitamins and / or minerals and / or phospholipids and / or choline.
[0205] Non-limiting examples of C10 to C44 saturated or unsatura...
Embodiment 1
[0456] Identification of nutritional drivers by cross-sectional analysis
[0457] From the above cohort, children up to 5 years of age who were fed different infant formulas during infancy were included in a large correlation analysis to examine the relationship between the nutritional composition of the formula and brain myelination. The nutritional composition of the 5 most commonly used formulas in this group was analyzed. A single general linear model (GLM) was constructed to simulate all quantified nutrients, fatty acid derivatives (especially ARA and DHA), and child age. Voxel-wise correlations were calculated, with significance defined as p<0.05, corrected for type I errors using a cluster-based correction method.
[0458] In the initial analysis, the inclusion of all nutrients resulted in an underpowered model. To reduce the number of variables in the model, we tested for correlations among variables. Using a conservative threshold of 0.9, we excluded variables (n...
Embodiment 2
[0462] Myelination trajectories according to longitudinal studies
[0463] Based on the available data, a longitudinal trajectory analysis was performed for two formulas containing different amounts of the identified nutritional driver, namely DHA (the composition of these formulas is reported in Table 2 below):
[0464] Table 2 :
[0465]
[0466] result in figure 1 reported in.
[0467] The graph shows that the higher the DHA content of the formula, the closer the myelination trajectory of infants fed that formula resembled that provided by human breastfeeding alone.
[0468] Based on the results reported in the experimental section, it has been demonstrated that nutritional compositions comprising fatty acid derivatives or mixtures thereof (such as ARA and / or DHA) determine the myelination trajectory in the brain in infants fed with such compositions Optimal (approximate to the trajectory determined by human breastfeeding). As discussed above, it is believed that...
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