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A kind of chitosan modified bioceramic material and preparation method thereof

A bio-ceramic material, chitosan modification technology, applied in ceramic products, other household appliances, household appliances, etc., can solve the problem of large molecular weight of chitosan, improve compressive strength, improve compressive strength and, The effect of promoting in vitro biodegradability

Active Publication Date: 2021-03-26
山东大学深圳研究院 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing modification methods of bioceramics, the molecular weight of chitosan used is too large to enter the pores of bioceramics, and the obtained bioceramic materials still have poor biocompatibility, mechanical properties, and degradation rate. Therefore, it is necessary to study a new bioceramic material

Method used

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  • A kind of chitosan modified bioceramic material and preparation method thereof
  • A kind of chitosan modified bioceramic material and preparation method thereof
  • A kind of chitosan modified bioceramic material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1) Preparation of CPP base material: Pour 100g of calcium dihydrogen phosphate raw material into a clean crucible. The upper part of the crucible should be covered but not sealed. ℃, heat preservation for 10h to carry out primary sintering, after the furnace cools down, take out the powder material for primary sintering, grind it into powder, then mix these powders with 1g of polyvinyl alcohol with a mass fraction of 5% to obtain a mixture, according to the ball water 1: Pour the ratio of 2:1 into a ball mill tank and mill at a speed of 230r / m for 60min. Dry the milled slurry at 50°C and pass it through a 200-mesh sieve. Mix 3:7 evenly, carry out dry pressing molding, and obtain the green body; finally, the pressed green body is raised to 400°C at a rate of 4°C / min and kept for 2h, and raised to 850°C at a rate of 4°C / min. Keep warm for 90 minutes, cool naturally with the furnace, take it out, and the porous CPP ceramic material is obtained.

[0066] 2) Pretreatment of...

Embodiment 2

[0070] 1) Preparation of CPP base material: Same as Example 1.

[0071] 2) Pretreatment of CPP base material: same as embodiment 1.

[0072] 3) preparation of chitosan sol: with embodiment 1

[0073] 4) Preparation of composite bioceramic material: take the chitosan solution prepared in step 3) as the immersion solution, and immerse the CPP base material obtained in step 2) into the immersion solution under a constant temperature water bath condition of 40°C, Soak for 6h, 12h, 24h, 36h, 48h respectively, then ultrasonically oscillate in the soaking solution for 5min, take it out and dry it at 55°C for 6h, then use 0.1mol / L NaOH solution, deionized water, and absolute ethanol to remove residual impurities , dried, that is.

Embodiment 3

[0075] 1) Preparation of CPP base material: Pour 100g of calcium dihydrogen phosphate raw material into a clean crucible. The upper part of the crucible should be covered but not sealed. ℃, keep warm for 15 hours for primary sintering, take out the primary sintered powder after the furnace cools down, grind it into powder, and then mix these powders with 0.1g of polyvinyl alcohol with a mass fraction of 10% to obtain a mixture, according to the ball water 1 Pour the ratio of 1:1 into a ball mill tank and mill at a speed of 300r / min for 20min, dry the milled slurry at 45°C and pass it through a 100-mesh sieve. Ratio 3:7 mixed evenly, carry out dry pressing molding (the condition of pressing molding is: pressure is 0.5MPa, hold pressure 2min), obtain green body; Hold at 300°C for 4 hours, raise to 700°C at a rate of 1°C / min, hold for 120 minutes, wait for the furnace to cool naturally, take it out, and the porous CPP ceramic material is obtained.

[0076] 2) Pretreatment of CPP...

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Abstract

The invention relates to chitosan modified bioceramics and a preparation method thereof, and belongs to the field of bioceramic preparation. The chitosan modified bioceramic is formed by a chitosan film layer and a porous calcium polyphosphate biocearmic substrate, wherein the surface of the porous calcium polyphosphate bioceramic susbtrate is uniformly coated with chitosan, and the chitosan enters gaps of calcium polyphosphate bioceramic. Composite bioceramic is prepared by covering the surface of the porous calcium polyphosphate bioceramic substrate with the chitosan which has low molecularweight by adopting an impregnation method, so that the compression strength is increased by three times than that of pure calcium phosphate ceramic while proper degradability of the composite bioceramic is ensured, a binding force between a coated film layer and the porous calcium polyphosphate bioceramic substrate is up to 24.93N, and the compression strength of a composite bioceramic material and the binding force between the film layer and the porous calcium polyphosphate substrate are improved to a large extent.

Description

technical field [0001] The invention relates to the field of preparation of bioceramic materials, in particular to a chitosan modified bioceramic material and a preparation method thereof. Background technique [0002] Bioceramics refer to ceramic materials that are implanted in living organisms and have certain functions. Its surface structure, friction coefficient, specific gravity, thermal conductivity and strength are very similar to bone. Bioceramics can be divided into three categories according to their activity in vivo: inert bioceramics, active bioceramics and absorbable bioceramics. Inert bioceramics refer to materials that undergo little change in living organisms. Active bioceramics refer to materials that have good biocompatibility but cannot degrade in vivo, mainly including dense hydroxyapatite, magnetic materials and bioactive glass. Absorbable bioceramics refer to materials that can be gradually degraded in vivo, participate in the metabolism of organisms...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C04B38/06C04B35/447C04B35/622C04B41/83
CPCC04B35/447C04B35/622C04B38/067C04B41/48C04B41/83C04B2235/6562C04B2235/6567C04B41/4539C04B38/0074
Inventor 陈传忠李慧君于慧君
Owner 山东大学深圳研究院
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