Squeezing roller device for dry granulator

Abstract

The invention discloses a squeeze roller device for a dry granulator. The device comprises a base frame with an upper cover plate, a driving roller device and a driven roller device, wherein the driving roller device and the driven roller device are mounted on the base frame and provided with squeeze rollers. An automatic gap adjusting device for adjusting the spacing between the driving roller device and the driven roller device is mounted at the bottom of the base frame; the driving roller device and the driven roller device are provided with a driving bearing base and a driven bearing baserespectively, the face, is opposite to the driving bearing base, of the driven bearing base is provided with a double-sided slope which tends to be parallel to the automatic gap adjusting device, andthe back face of the double-sided slope on the driven bearing base abuts against a hydraulic cylinder pushing device; the automatic gap adjusting device includes a left rotary screw rod, a right rotary screw rod and a servo motor driving the left and right rotary screw rods to rotate, wherein the two ends of the left rotary screw rod and the two ends of the right rotary screw rod are provided withsliding blocks. By using the device, high-precision automatic gap adjustment can be conducted on the driving roller device and the driven roller device, the device is simple in structure and convenient to operate, and the production efficiency is improved.

Description

technical field [0001] The invention belongs to the technical field of dry granulation technology of medicines, and in particular relates to a squeeze roller device of a dry granulator. Background technique [0002] The pharmaceutical industry is widely involved in the processing of various active pharmaceutical raw materials and one or more excipients. Most of these raw materials are fine powders. Due to the different particle sizes, uneven densities and fluidity of these powders Not good, easy to layer. Therefore, these APIs must go through a key process - granulation, before they can be compressed into tablets, filled in capsules or directly packaged in the form of granules. [0003] There are currently four granulation processes: old-fashioned wet granulation (GMP cannot pass), wet mixing granulation, dry granulation, and one-step boiling granulation. The latter three methods have their own characteristics. Granulation is the most traditional granulation method, and dr...

AI Technical Summary

Problems solved by technology

[0005] At present, the minimum gap between the extrusion rollers of the dry granulator on the market is fixed, and the automatic gap adjustment cannot be realized. The gap between the rollers can only be completed by the pre-pressure when the drug is fed, and some heat-sensitive For drugs with high sugar content, once the pre-pressure is high, the drug will melt and agglomerate, and it is impossible to overcome the self-gravity between the extrusion rollers to complete the gap adjustment of the rollers, which greatly restricts the scope of application of the dry granulator

For dry granulation of some special drugs, it is difficult to realize the automatic gap adjustment control between the extrusion rollers with the existing technology

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