Preparation method of oral liquid for bronchitis patients

A bronchitis and oral liquid technology, applied in the field of oral liquid, can solve the problems of unfavorable storage of medicines, unsuitable for children to take, bad taste, etc., to achieve sustainable development, rapid treatment of bronchitis, improve solubility and selection sexual effect

Inactive Publication Date: 2018-06-22
磐安富晟食品科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, before taking the medicine, the medicine needs to be decocted into a medicament, which is not conducive to preservation, and the taste is not good, so it is not suitable for children to take

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The preparation method of the oral liquid for patients with bronchitis comprises the extraction of Fritillaria alkaloids, preparation of sweet tea concentrate, decoction and preparation of finished products, which specifically includes the following steps:

[0017] 1) Extraction of Fritillaria alkaloids: Pack Fritillaria and diatomaceous earth with a weight ratio of 8:1 into a column, tighten the column, connect to the extraction kettle, set the temperature at 55°C, pressure at 28MPa, and flow rate of entrainer at 0.3mL / min, CO 2 The flow rate is 2L / h, and after the parameters are stable, extract for 2 hours to obtain Fritillaria alkaloids. The entrainer is 90% ethanol solution, which contains 0.034% mannitol, and 0.6% L-mannitol in mannitol. Alkaloids in Fritillaria are weakly polar substances. When high-concentration ethanol is used as an entrainer, the extraction rate of alkaloids in Fritillaria is high, and the addition of mannitol can greatly increase the relation...

Embodiment 2

[0024] The preparation method of the oral liquid for patients with bronchitis comprises the extraction of Fritillaria alkaloids, preparation of sweet tea concentrate, decoction and preparation of finished products, which specifically includes the following steps:

[0025] 1) Extraction of Fritillaria alkaloids: Pack Fritillaria and diatomaceous earth with a weight ratio of 6:1 into a column, tighten the column, connect it to the extraction kettle, set the temperature at 65°C, the pressure at 25MPa, and the flow rate of the entrainer at 0.5mL / min, CO 2 The flow rate is 1L / h, and after the parameters are stable, extract for 3 hours to obtain Fritillaria alkaloids. The entrainer is 80% ethanol solution, which contains 0.042% mannitol, and mannitol contains 0.5% L-mannitol;

[0026] 2) Preparation of sweet tea concentrate: add deionized water to sweet tea leaves according to the ratio of material to liquid 1:15 (g / mL), then add coumarin with a dry weight of 0.04‰ of sweet tea lea...

Embodiment 3

[0032] The preparation method of the oral liquid for patients with bronchitis comprises the extraction of Fritillaria alkaloids, preparation of sweet tea concentrate, decoction and preparation of finished products, which specifically includes the following steps:

[0033] 1) Extraction of Fritillaria alkaloids: Pack Fritillaria and diatomaceous earth with a weight ratio of 7:1 into a column, tighten the column, connect to the extraction kettle, set the temperature at 60°C, pressure at 26MPa, and flow rate of entrainer at 0.4mL / min, CO 2 The flow rate is 1.5L / h, and after the parameters are stable, extract for 2.5h to obtain Fritillaria alkaloids. The entrainer is 85% ethanol solution, which contains 0.04% mannitol, and 0.55% L-mannitol in mannitol alcohol;

[0034] 2) Preparation of sweet tea concentrate: Add deionized water to sweet tea leaves according to the ratio of material to liquid 1:18 (g / mL), and then add coumarin with a dry weight of 0.035‰ of sweet tea leaves. Ul...

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PUM

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Abstract

The invention discloses a preparation method of an oral liquid for bronchitis patients. The preparation method comprises the following steps: loading a column of Zhejiang Fritillary and diatomaceous earth into an extraction kettle, and supercritically extracting alkaloids of Zhejiang Fritillary; adding deionized water and coumarin to sweet tea leaves; after ultrasonic extraction, performing roughfiltration and microfiltration, and obtaining a sweet tea concentrate through freeze-concentration of microfiltration liquid; adding water to formula amounts of loquat leaf powder, ginkgo seed powder,herba ephedrae, mature vinegar, fructus crataegi, almonds and rock candy, decocting to obtain decoction liquid, and filtering; adding formula amounts of the sweet tea concentrate, the alkaloids of Zhejiang Fritillary, potassium sorbate and fruit essence to the decoction liquid, mixing uniformly, filtering, and canning to obtain the oral liquid. The beneficial effects are as follows: the preparation method of the oral liquid provided by the invention is simple; the preparation process has no adverse effect on the environment; sources of raw materials are convenient; the storage period is long;the oral liquid obtained has the functions of relieving cough, reducing phlegm, relieving asthma and diminishing inflammation, and can treat bronchitis rapidly and protect teeth of pediatric patientsat the same time.

Description

technical field [0001] The invention relates to an oral liquid, in particular to a preparation method of the oral liquid for patients with bronchitis. Background technique [0002] Acute bronchitis is a common respiratory disease in pediatrics. It is often secondary to upper respiratory tract infection, and the trachea and bronchi are involved at the same time. Therefore, it is also called acute tracheo-bronchitis. The main clinical manifestations are cough and expectoration. The prognosis of the disease is generally good, but due to the poor physical condition of the child, improper care by the parents or mistreatment, the disease can be delayed and the cough recurs, which will eventually affect the growth and development of the child and increase the psychological and economic burden on the parents. . Therefore, how to effectively prevent and treat acute bronchitis has become an urgent issue for pediatricians. [0003] At present, Western medicine mainly uses symptomatic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8966A61K36/899A61K9/08A61P11/00A61P11/14A61P11/10A61K31/7016
CPCA61K9/0095A61K31/7016A61K36/16A61K36/17A61K36/185A61K36/73A61K36/734A61K36/736A61K36/8966A61K36/899A61K2236/331A61K2236/55A61K2300/00
Inventor 谢剑兵杨艳
Owner 磐安富晟食品科技有限公司
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