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Mussaenda pubescens extract and preparation and application thereof in treating amygdalitis

A technology of Jade Leaf Golden Flower and extract, which is applied in the directions of drug combinations, plant raw materials, medical preparations containing active ingredients, etc., to achieve the effects of reducing tonsil swollenness, significant effect, and simple preparation.

Inactive Publication Date: 2018-06-22
GUANGXI UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the application of the ethyl acetate-butyl acetate extract of Yuyejinhua to tonsillitis has not been reported.

Method used

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  • Mussaenda pubescens extract and preparation and application thereof in treating amygdalitis

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The preparation of embodiment 1 Jade leaf golden flower extract

[0034] Follow the steps below:

[0035] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 60-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0036] (2) According to the ratio of Yuye Jinhua powder and isopropanol aqueous solution at a ratio of 1:5, reflux extraction at the azeotropic point of 88-92°C for 60-300min, filter, concentrate under reduced pressure, and collect fractions;

[0037] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:20, soak at 37°C for 40 minutes, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2000MHz, microwave The power is 400W, the extraction time is 5min, the liquid is separated, the organic phase is collected, and the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure to obtain the ethyl acetate-butyl acetate ...

Embodiment 2

[0038] The preparation of embodiment 2 Jade leaf golden flower extract

[0039] Follow the steps below:

[0040] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 100-mesh sieve to obtain Jade Leaf Golden Flower powder;

[0041] (2) According to the ratio of Yuyejinhua powder and isopropanol aqueous solution at a ratio of 1:10, reflux extraction at the azeotropic point of 88-92°C for 60-300min, filter, concentrate under reduced pressure, and collect fractions;

[0042] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:25, soak at 40°C for 50 minutes, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction conditions are microwave frequency 2270MHz, microwave The power is 500W, the extraction time is 7min, the liquid is separated, the organic phase is collected, and the ethyl acetate-butyl acetate solvent is removed by rotary evaporation under reduced pressure to obtain the ethyl acetate-butyl acetate...

Embodiment 3

[0043] The preparation of embodiment 3 Jade leaf golden flower extract

[0044] Follow the steps below:

[0045] (1) Dried Jade Leaf Golden Flower, pulverizing, crossing a 120 mesh sieve to obtain Jade Leaf Golden Flower powder;

[0046] (2) According to the ratio of Yuyejinhua powder and isopropanol aqueous solution at a ratio of 1:20, reflux extraction at the azeotropic point of 88-92°C for 300 minutes, filter, concentrate under reduced pressure, and collect fractions;

[0047] (3) Add pure water to the distillate in step (2) according to the volume ratio of 1:30, warm soak at 42°C for 40-60min, and then use ethyl acetate-butyl acetate microwave extraction for 3 times, the extraction condition is microwave frequency 2500MHz , microwave power 600W, extraction time 10min, separate the liquid, collect the organic phase, remove the ethyl acetate-butyl acetate solvent by rotary evaporation under reduced pressure, and obtain the ethyl acetate-butyl acetate extract of Jade leaf Ji...

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Abstract

The invention provides a mussaenda pubescens extract and preparation and application thereof in treating amygdalitis, A preparation method of the mussaenda pubescens extract comprises the following steps that 1, mussaenda pubescens is dried and smashed to obtain mussaenda pubescens powder; 2, the mussaenda pubescens powder and an isopropanol aqueous solution are mixed, the mixture is subjected torefluxing, filtering and concentration, and fractions are collected; 3, pure water is added into the fractions obtained in step 2, warm maceration, ethyl acetate-butyl acetate microwave extraction andliquid separation are conducted, an organic phase is collected, rotary evaporation is performed to remove a solvent, and the mussaenda pubescens extract is obtained. Radix astragali, herba schizonepetae, honeysuckle and platycodon grandiflorum are smashed, mixed, decocted, filtered and concentrated to obtain an anti-inflammatory composition water extract; the diluted mussaenda pubescens ethyl acetate-butyl acetate extract is added, and solid powder is obtained after spray drying. The mussaenda pubescens extract has an obvious amygdalitis treating effect.

Description

technical field [0001] The invention relates to the technical field of extracting traditional Chinese medicines, in particular to the extract of Jade Leaf Golden Flower and its preparation, and in particular to the application of the extract in treating tonsillitis. Background technique [0002] Tonsillitis usually refers to non-specific inflammation of the tonsils located in the throat, mostly caused by viral or bacterial infections. Clinically, it is often manifested as tonsil enlargement, congestion, a large number of neutrophil infiltration, and accompanied by fever, sore throat and other symptoms. Clinically, antibiotics are used to treat tonsillitis. Due to the continuous increase of drug-resistant bacteria, the symptoms are relieved slowly, and the treatment effect is not satisfactory. It is very easy to cause various complications and lead to infection of adjacent organs. [0003] Yuyejinhua comes from the dry stems and roots of Yuyejinhua plant of Rubiaceae Yuyejin...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/14A61P11/04A61K125/00
CPCA61K9/14A61K36/346A61K36/355A61K36/481A61K36/538A61K36/74A61K2236/331A61K2236/333A61K2236/39A61K2236/51A61K2300/00
Inventor 赵立春张谦华
Owner GUANGXI UNIV OF CHINESE MEDICINE
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