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Bioactive glass composite film as well as preparation method and application thereof

A technology of bioactive glass and composite film, applied in the field of oral biomedical materials, to achieve the effect of promoting remineralization, promoting recovery and avoiding drug resistance

Active Publication Date: 2018-06-22
AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes an improved method used to treat teeth that have become infected due to bacteria overgrowth on their roots. By placing this special material under regular intervals around these areas, which gradually dissolves away from plaque buildup, they are able to slow down the process of causing harmful microorganisms like those responsible for gingivitis without producing any side effects such as medications. These compositions also help healing damaged hardened enamel layers when applied topically, improving overall health outcomes compared to other methods currently available. Overall, this innovative technical solution helps prevent more serious complications related to periodonitus than current solutions.

Problems solved by technology

This patented technical problem addressed in this patent describes how to efficiently treat periodontochea disease caused by dental caries without causing pain or discomfort symptoms during therapy while maintaining effective levels over several months' duration.

Method used

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  • Bioactive glass composite film as well as preparation method and application thereof
  • Bioactive glass composite film as well as preparation method and application thereof
  • Bioactive glass composite film as well as preparation method and application thereof

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preparation example Construction

[0055] In addition, the present invention also provides a method for preparing the bioactive glass composite film, which specifically includes the following steps:

[0056] 1) Polylactic acid-glycolic acid terminal activation

[0057]

[0058] Dissolve polylactic acid-glycolic acid in organic solvent A (mixture of one or more of methanol, ethanol, ether, acetonitrile, chloroform, methylene chloride, dimethyl sulfoxide), add DCC (N, N-di Cyclohexylcarbodiimide) and N-hydroxyl-succinimide, add catalytic amount of triethylamine, react at room temperature for 24h, TLC thin-layer plate shows that the carboxyl group therein disappears and stops the reaction, and the reaction solution is 5% sodium bicarbonate The solution is quenched, and the product is extracted with an organic solvent B (petroleum ether, ethyl acetate or a mixture of the two), suction filtered, and dried by adding a desiccant under vacuum conditions to obtain end-activated polylactic acid-glycolic acid ,spare; ...

Embodiment 1

[0068] A preparation method of the bioactive glass composite membrane, specifically comprising the following steps:

[0069] 1) Polylactic acid-glycolic acid terminal activation

[0070]

[0071] Dissolve 10 g of polylactic acid-glycolic acid in 30 ml of dichloromethane, add 3.6 g of DCC (N, N-dicyclohexylcarbodiimide) and 2.8 g of N-hydroxy-succinimide, and add 0.5 g of triethyl Amine, reacted at room temperature for 24 hours, TLC thin-layer plate showed that the carboxyl group disappeared and stopped the reaction. The reaction solution was quenched with 50ml of 5% sodium bicarbonate solution, and the product was extracted with 20ml of ethyl acetate, filtered by suction, and added to dryness under vacuum. The agent was dried to obtain 7.3 g of end-activated polylactic acid-glycolic acid, which was set aside;

[0072] 2) Terminal amination synthesis of hyaluronic acid

[0073] Dissolve 3.4g of N,N-diethylethylenediamine in 100ml of phosphate buffer solution with a pH of 8...

Embodiment 2

[0099] An application of the bioactive glass composite film in the preparation of drugs for the auxiliary treatment of periodontitis, the composite film of the present invention is placed in the periodontal pocket during or after the operation, and can be slowly degraded and slowly release biological substances. Active glass nanoparticles.

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Abstract

The invention discloses a bioactive glass composite film as well as a preparation method and application thereof. The composite film is a thin flaky degradable composite material, and is prepared frombioactive glass powder by using hyaluronic acid and polymer lactic acid-polyglycolic acid as carriers through film forming. The preparation method concretely comprises the following steps of (1) polylactic acid-hydroxyacetic acid end position activation; (2) hyaluronic acid tail end amination synthesis; (3) hyaluronic acid-polylactic acid-hydroxyacetic acid copolymer carrier synthesis; (4) hyaluronic acid-polylactic acid-hydroxyacetic acid copolymer gel dispersion preparation; (5) hyaluronic acid-polylactic acid polymer-bioactive glass composite film preparation. The composite film slowly releases bioactive glass nanometer particles; good biocompatibility is achieved; the long-effect anti-inflammatory effects can be achieved; drug resistance cannot be generated; the periodontium growth ispromoted; the dentinal tubule is sealed; the goal of reducing dentine hypersensitivity after the periodontal surgery can be achieved.

Description

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Claims

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Application Information

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Owner AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV
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