Preparative separation and purification device

A technology for separation, purification and holding devices, which is applied in separation methods, measurement devices, material separation, etc., to achieve the effect of improving recovery efficiency

Active Publication Date: 2018-06-08
SHIMADZU SEISAKUSHO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, in such a method, it takes several hours to about a day just for the evaporation / drying curing treatment

Method used

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  • Preparative separation and purification device
  • Preparative separation and purification device
  • Preparative separation and purification device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0037] figure 1 It is a schematic configuration diagram of a separation and purification apparatus according to an embodiment of the present invention. This separation and purification device is a device for recovering, from the trap column, the target component separated by a separation liquid chromatograph (not shown) and captured by the adsorbent filled in the trap column.

[0038] The column frame 10 (holding device in the present invention) holds the well column 20 upright with the inlet end facing down and the outlet end facing up. In addition, target components separated by a separation liquid chromatograph (not shown) are preliminarily captured in the trap column 20 .

[0039] A recovery container 31 for recovering the target component eluted from the trap column 20 is housed in the recovery container rack 30 .

[0040] Above the column rack 10 and the recovery container rack 30 , a recovery head 40 for sending the eluent from the trap column 20 to the recovery conta...

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Abstract

The present invention prevents water from a trap column in which a large amount of water is remaining from mixing with a recovered solution while enhancing the efficiency of the collection of a targetcomponent. A target component is collected using a preparative separation and purification device having a holding means 10 for holding a trap column 20 in which the target component has been captured such that an entrance end of the trap column 20 is down and an exit end is up, a liquid feeding means 81 for feeding a first solvent having compatibility with the water remaining in the trap column20 and a second solvent having low compatibility with water and high compatibility with the first solvent into the trap column 20 in that order, a flow-path switching means 45 for connecting the exitend of the trap column 20 to a waste liquid flow path 46 and a collection flow path 42, and a control unit 64 for controlling the flow-path switching means 45 so that solution including water flows into the waste liquid flow path 46 during the discharge of the solution from the trap column 20 and solution including the first and second solvents flows into the collection flow path 42 when the solution is discharged.

Description

technical field [0001] The present invention relates to a separation and purification device for separating and recovering one or more components contained in a solution by using a liquid chromatograph. Background technique [0002] In the field of pharmaceuticals, a separation and purification system using a liquid chromatograph is used for the purpose of collecting samples for storing various compounds obtained by chemical synthesis as a library or for detailed analysis. As such a separation and purification system, systems described in Patent Document 1 and Patent Document 2 are known. [0003] In the separation and purification systems described in Patent Documents 1 and 2, target components (compounds) in a sample solution are temporally separated by a liquid chromatograph, and each target component is introduced into and temporarily captured in a separate trap. column. Then, a solvent (solvent for eluting) flows through each trap column, and by eluting the target com...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/80G01N30/26
CPCG01N30/84G01N2030/085B01D15/14B01D15/161B01D15/163B01D15/247G01N30/80G01N30/32G01N30/38G01N2030/328G01N2030/385
Inventor 山崎智之
Owner SHIMADZU SEISAKUSHO CO LTD
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