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PLA (polylactic acid)-based bone meal for dental department and preparation method of PLA-based bone meal

A technology based on dental and bone powder, applied in the field of PLA-based dental bone powder and its preparation, can solve the problems of poor hydrophilicity, poor biocompatibility, unfavorable cell adhesion and proliferation, etc., and achieve low production cost and good biocompatibility , Improve the effect of bone repair effect

Active Publication Date: 2018-06-01
BEIJING ALLGENS MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Aiming at the problems of poor biocompatibility and hydrophilicity of the existing dental bone powder, which is not conducive to the adhesion and proliferation of cells on the bone powder material, the present invention provides a dental bone powder with good biocompatibility and excellent hydrophilic effect PLA-based dental bone powder can improve the effect of bone repair, and also has good imaging effect, lower production cost, and is convenient for clinical application

Method used

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  • PLA (polylactic acid)-based bone meal for dental department and preparation method of PLA-based bone meal
  • PLA (polylactic acid)-based bone meal for dental department and preparation method of PLA-based bone meal
  • PLA (polylactic acid)-based bone meal for dental department and preparation method of PLA-based bone meal

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preparation example Construction

[0108] In some embodiments, the preparation method of the porous hydroxyapatite includes the following steps:

[0109] (a) preparing polyvinyl alcohol solution;

[0110] (b) preparing hydroxyapatite suspension;

[0111] (c) adding the polyvinyl alcohol solution to the hydroxyapatite suspension, stirring for a first time, then adding PMMA microspheres, and stirring for a second time to obtain a sintered base liquid;

[0112] (d) placing the sintering base liquid in a sintering device for sintering to obtain a sintered material;

[0113] The sintering includes the following stages:

[0114] The first stage: the heating rate is 4-5°C / min, the target temperature is 200-220°C, and the constant temperature time is 1800-1850min;

[0115] The second stage: the heating rate is 4-5°C / min, the target temperature is 350-400°C, and the constant temperature time is 300-350min;

[0116] The third stage: the heating rate is 4-5°C / min, the target temperature is 1000-1115°C, and the constan...

Embodiment 1

[0170] A PLA-based dental bone powder, the preparation components comprising:

[0171] L-polylactic acid;

[0172] Mineralized collagen, the mass is 150% of the mass of L-lactic acid;

[0173] Porous hydroxyapatite with a mass of 30% of the mass of poly-L-lactic acid; and

[0174] Soybean lecithin, the mass is 20% of the mass of L-lactic acid.

Embodiment 2

[0176] A PLA-based dental bone powder, the preparation components comprising:

[0177] L-polylactic acid;

[0178] Mineralized collagen, the mass is 50% of the mass of L-lactic acid;

[0179] Porous hydroxyapatite having a mass of 25% of the mass of poly-L-lactic acid; and

[0180] Egg yolk lecithin, the mass is 5% of the mass of L-lactic acid.

[0181] Among them, the molecular weight of L-polylactic acid is 100,000;

[0182] Porous hydroxyapatite is: particles that can pass through a 20-mesh sieve and be retained by a 60-mesh sieve.

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Abstract

The invention relates to PLA (polylactic acid)-based bone meal for the dental department and a preparation method of PLA-based bone meal. The bone meal for the dental department is prepared from poly-L-lactic acid, mineralized collagen with the mass being 50%-150% of that of poly-L-lactic acid, porous hydroxyapatite with the mass being 25%-30% of that of poly-L-lactic acid and lecithin with the mass being 5%-20% of that of poly-L-lactic acid. The preparation method comprises the steps as follows: preparation of a poly-L-lactic acid solution, blending, mold filling, freeze-drying, analysis, crushing and screening. The PLA-based bone meal material for the dental department has good biocompatibility and an excellent hydrophilic effect, can improve the bone repair effect, also has a good developing effect and is convenient to apply clinically.

Description

technical field [0001] The invention relates to the technical field of oral implant bone powder materials, in particular to PLA-based dental bone powder and a preparation method thereof. Background technique [0002] In dental surgery, there are many situations that may cause bone defect or bone deficiency in patients after surgery, such as bone defect after periodontal cyst extraction, and bone deficiency caused by alveolar ridge atrophy after tooth extraction. These conditions often limit the patient's postoperative bone healing and the effect of subsequent dental implants, so bone implants are required. The current gold method is mainly to use autologous bone for transplantation, but its application is limited due to its limited source and certain postoperative complications in the donor site. Allogeneic bone grafts have potential antigenicity and the risk of disease transmission. Therefore, artificial bone repair materials, also known as bone powder, have become a popul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/56A61L27/50
CPCA61L27/46A61L27/50A61L27/56A61L2430/12C08L89/00C08L67/04
Inventor 崔云宋天喜何志敏朱金亮胡艳丽仇志烨崔菡
Owner BEIJING ALLGENS MEDICAL SCI & TECH
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