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Preparation method of dynamic pH response chain based on boric acid type metal organic complex

A metal-organic and boric acid-based technology, applied in the field of preparation of biomedical functional materials, can solve the problems of few reports

Active Publication Date: 2018-05-29
镇江卡博医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, metal-organic complexes have been widely used in photocatalysis, separation of environmental pollutants, bioseparation and other fields, but there are few reports on drug loading.

Method used

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  • Preparation method of dynamic pH response chain based on boric acid type metal organic complex
  • Preparation method of dynamic pH response chain based on boric acid type metal organic complex
  • Preparation method of dynamic pH response chain based on boric acid type metal organic complex

Examples

Experimental program
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Effect test

Embodiment 1

[0034]First 20mL of ethanol and 20mL of distilled water were mixed, then 0.4g of dopamine hydrochloride was added, and stirred and dispersed with a magnet for 20min; the obtained solution was slowly added with 1mL of ammonia solution (28%-30% ), the solution immediately changed from yellow to dark brown and continuously stirred for 12 hours, and was washed with distilled water several times, and dried for 12 hours at 50 degrees to prepare polydopamine nanoparticles (PDA); then the prepared 80mgPDA , 40mg of zinc nitrate hexahydrate, 10mL of absolute ethanol, and 10mL of N,N-dimethylformamide (DMF) were added to the reaction ax of polytetrafluoroethylene, then 7mg of BBDC and 7mg of BTC were added, and in Hydrothermal polymerization in a blast drying oven at 100°C for 6 hours, then cooled to room temperature, washed with distilled water several times, and finally dried in vacuum at 50°C, and then repeated the above steps 3 times to prepare PDA@CP. Then the obtained PDA@CP was a...

Embodiment 2

[0036] First 25mL of ethanol and 25mL of distilled water were mixed, then 0.5g of dopamine hydrochloride was added, and stirred and dispersed with a magnet for 30min; the resulting solution was slowly added to 2mL of ammonia solution (28%-30% ), the solution immediately changed from yellow to dark brown and continuously stirred for 24 hours, and was washed with distilled water several times, and dried at 60 degrees for 24 hours to prepare polydopamine nanoparticles (PDA); then the prepared 100mgPDA , 50mg of zinc nitrate hexahydrate, 12.5mL of absolute ethanol, and 12.5mL of N,N-dimethylformamide (DMF) were added to the polytetrafluoroethylene reaction ax, and then 8mg of BBDC and 8mg of BTC were added, And hydrothermally polymerized in a blast drying oven at 120°C for 12 hours, then cooled to room temperature, washed with distilled water several times, and finally dried in vacuum at 60°C, and then repeated the above steps 3 times to prepare PDA@CP. Then the obtained PDA@CP wa...

Embodiment 3

[0038] First 30mL of ethanol and 30mL of distilled water were mixed, then 0.6g of dopamine hydrochloride was added, and stirred and dispersed with a magnet for 40min; the resulting solution was slowly added to 3mL of ammonia solution (28%-30% ), the solution immediately changed from yellow to dark brown and continuously stirred for 48 hours, and was washed with distilled water several times, and dried for 48 hours at 70 degrees to prepare polydopamine nanoparticles (PDA); then the prepared 120mgPDA , 60mg of zinc nitrate hexahydrate, 15mL of absolute ethanol, and 15mL of N,N-dimethylformamide (DMF) were added to the polytetrafluoroethylene reaction ax, then 9mg of BBDC and 9mg of BTC were added, and in Hydrothermal polymerization was carried out at 140°C for 24 hours in a blast drying oven, then cooled to room temperature, washed with distilled water several times, and finally dried in vacuum at 60°C, and then the above steps were repeated 3 times to prepare PDA@CP. Then the o...

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Abstract

The invention belongs to the technical field of biomedical functional material preparation, and relates to a preparation method of a dynamic pH response chain based on a boric acid type metal organiccomplex. Therefore, a boronate ligand is introduced by utilizing the metal organic complex, then an anti-cancer drug doxorubicin (DOX) is loaded on through the porous structure of the metal organic complex, and hydrophilic biologic chain (PEG-NHS-PDA) is attached to serve as the dynamic response chain to achieve the purpose of sustained releasing and preventing the anti-cancer drug from releasingat will. Finally sialic acid on the surfaces of cancer cells is identified through the metal organic complex, and growing of the cancer cells is inhibited through a thermal therapy effect.

Description

technical field [0001] The invention belongs to the technical field of preparation of biomedical functional materials, and relates to a preparation method of a dynamic pH response chain based on a boric acid metal organic complex. Background technique [0002] With the continuous understanding of tumor cell biology and genetics, new treatment methods and means are also emerging, cancer treatment research has made considerable progress, and tumor hyperthermia has become a new hot spot. The advantages of hyperthermia are reflected in the advantages of small side effects, obvious effect, and short treatment cycle. The original idea of ​​cancer treatment mainly relied on the delivery of antitumor chemotherapy drugs. However, during drug delivery, anticancer drugs are often released and damage normal cells and tissues, causing unwanted drug side effects. Therefore, in order to improve the utilization efficiency of drug carriers, it is necessary to develop multifunctional drug c...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K31/704A61K47/34A61P35/00
CPCA61K31/704A61K41/0052A61K47/34A61K2300/00
Inventor 刘树成潘建明陈学平白雪
Owner 镇江卡博医药科技有限公司
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