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System and method for focusing or separating submicron nano-particles on the basis of non-Newtonian effect

A non-Newtonian effect and nanoparticle technology, applied in chemical instruments and methods, laboratory containers, special data processing applications, etc., can solve the problems of manufacturing difficulty and rising production costs, so as to improve scalability and avoid irreversibility Non-destructive, easy-to-operate effects

Inactive Publication Date: 2018-05-25
INST OF MECHANICS - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of sub-micron or nano-scale pipes leads to a substantial increase in manufacturing difficulty and production costs

Method used

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  • System and method for focusing or separating submicron nano-particles on the basis of non-Newtonian effect
  • System and method for focusing or separating submicron nano-particles on the basis of non-Newtonian effect
  • System and method for focusing or separating submicron nano-particles on the basis of non-Newtonian effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This example provides the attached figure 1 The shown system for focusing and separating submicron nanoparticles based on the non-Newtonian effect, the system includes:

[0043] Delivery device 1 for delivering working fluid with non-Newtonian fluid effect;

[0044] Microfluidic unit 2 containing microchannels (Liu, C.; Xue, C.; Chen, X.; Shan, L.; Tian, ​​Y.; Hu, G. Size-Based Separation of Particles and Cells Utilizing Viscoelastic Effectsin Straight Microchannels.Anal.Chem.2015,87,6041-6048.), the microfluidic unit 2 communicates with the delivery device 1 through a pipeline, and is used for submicron nanoparticles in the working fluid delivered by the delivery device 1 Focusing in the microchannel;

[0045] A bifurcated outlet 3 arranged at the end of the microfluidic unit 2, the central branch of the bifurcated outlet 3 is used to focus submicron nanoparticles;

[0046] A collection device 4 for collecting target submicron nanoparticles connected to the branch o...

Embodiment 2

[0068] This example presents systems and methods for focusing DNA molecules.

[0069] This example provides the attached Image 6 The system shown for focusing submicron nanoparticles based on the non-Newtonian effect includes:

[0070] Delivery device 1 for delivering working fluid with non-Newtonian fluid effect;

[0071] A microfluidic unit 2 comprising a microchannel, the microfluidic unit 2 is connected to the delivery device 1 through a pipeline, and is used to separate the submicron nanoparticles in the working fluid delivered by the delivery device 1 in the microchannel;

[0072] A branch outlet 3 is provided at the end of the microfluidic unit 2, and the central branch of the branch outlet 3 is used to collect and focus submicron nanoparticles;

[0073] A collection device 4 for collecting target submicron nanoparticles is connected to the central branch of the bifurcation outlet 3 .

[0074] In the present invention, the delivery of the working fluid by the delive...

Embodiment 3

[0094] This example presents systems and methods for isolating submicron nanoparticles.

[0095] This example provides the attached Figure 9 The shown system for focusing and separating submicron nanoparticles based on the non-Newtonian effect, the system includes:

[0096] Delivery device 1 for delivering working fluid with non-Newtonian fluid effect;

[0097] A microfluidic unit 2 comprising a microchannel, the microfluidic unit 2 communicates with the delivery device 1 through a pipeline, and is used to separate the submicron nanoparticles in the working fluid delivered by the delivery device 1 in the microchannel; in order to improve Separation throughput, the microfluidic unit 2 uses a parallel structure;

[0098] The branch outlet 3 provided at the end of the microfluidic unit 2, the central branch 31 of the branch outlet 3 is used to separate submicron nanoparticles with a larger diameter, and the side branch 32 of the branch outlet 3 is used to separate particles wi...

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Abstract

The invention provides a system and a method for focusing or separating submicron nano-particles on the basis of a non-Newtonian effect. The system comprises a conveying device, a microfluidics unit,a turnoff outlet and a collection device, wherein the conveying device is used for conveying work fluid with a non-Newtonian fluidics effect; the microfluidics unit contains a micro-channel and is communicated with the conveying device through a pipeline for separating the submicron nano-particles conveyed by the conveying device in the work fluid in the micro-channel; the turnoff outlet is arranged on the tail end of the microfluidics unit, flexibly adapts to focusing or separating requirements, the center branch of the turnoff outlet is used for collecting focused submicron nano-particles, and the side branch of the turnoff outlet is used for separating different submicron nano-particles; and the collection device is independently connected with the turnoff outlet for collecting the submicron nano-particles. The system can be flexibly cooperated with various device designs to realize the focusing or separating of the submicron nano-particles, specific immunity reaction is not used, and the system is simple in manufacture and operation and is convenient and parallel.

Description

technical field [0001] The invention belongs to the technical field of particle separation, and in particular relates to a system and a manufacturing method for focusing and separating submicron nanoparticles based on the non-Newtonian effect. Background technique [0002] Continuous and efficient focusing and separation of submicron nanoparticles is of great significance in many applications and research fields such as medical treatment, pharmaceuticals, chemistry, biology, and high-resolution medical imaging. In these fields, methods such as ultracentrifugation, pore membrane filtration, and specific immunoadsorption are widely used to separate submicron nanoparticles. These separation methods often result in the loss of submicron nanoparticles. Ultracentrifugation requires 10 5 The acceleration of gravity may cause damage to sensitive biological submicron nanoparticles, and the preparation steps are cumbersome, time-consuming and dangerous. Porous membrane filtration i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06F17/50B01L3/00
CPCB01L3/5027B01L2200/10B01L2300/0861G06F30/17G06F30/20
Inventor 胡国庆刘超孙佳姝
Owner INST OF MECHANICS - CHINESE ACAD OF SCI
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