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A kind of anti-acne and antipruritic and detumescence composition and preparation method thereof

A technology for relieving itching and detumescence and a composition, which is applied in the field of biomedicine, can solve problems such as unsatisfactory effect, it is difficult to quickly relieve itching and detumescence, and it is not suitable for people with sensitive skin, etc. Itching effect

Active Publication Date: 2021-03-16
成都山信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, soap or baking soda can be used to dilute and apply locally to relieve symptoms, but the effect is not ideal, and it is difficult to achieve the effect of quickly relieving itching and reducing swelling
For the antipruritic and swelling after mosquito bites, the antipruritic medicines on the market are mainly essential oils and cool oils, which contain alcohol and are not suitable for people with sensitive skin. As for hormone drugs, the antipruritic effect is very obvious, but pregnant women Children and other special populations need to be used with caution

Method used

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  • A kind of anti-acne and antipruritic and detumescence composition and preparation method thereof
  • A kind of anti-acne and antipruritic and detumescence composition and preparation method thereof
  • A kind of anti-acne and antipruritic and detumescence composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Extraction process screening of honeysuckle, dandelion, Sophora flavescens and Salvia miltiorrhiza extracts:

[0023] Extraction method of honeysuckle extract: add 5-15 times of water to soak the honeysuckle medicinal material for 12 hours; extract the medicinal material mixture at 70-90°C for 0.5-2 hours, filter to obtain the extract; concentrate the extract at 60°C to 1:1.25 (g:ml) , cooled to 35-45°C to obtain the honeysuckle extract.

[0024] Extraction method of dandelion extract: crush the dandelion medicinal material to below 2.0 cm, add 5 to 15 times of water to soak for 12 hours; extract the medicinal material mixture at 70 to 90 °C for 0.5 to 2 hours, and filter to obtain the extract; concentrate the extract at 60 °C to 1: 1.25 (g:ml), cooled to 35 ~ 45 ℃, to get dandelion extract.

[0025] Sophora flavescens extract extraction method: crush the dandelion medicinal material to below 2.0 cm, add 5 to 15 times of water to soak for 12 hours; extract the medicina...

Embodiment 2

[0049] The preparation method of the anti-acne, antipruritic and detumescence composition: soak in carbopol overnight, heat at 40°C, stir for 2h; add glycerin, stir for 0.5h; add 1,3-butanediol, stir for 0.5h; add the extracted honeysuckle , dandelion, Sophora flavescens, and Salvia miltiorrhiza extract, stirring for 0.5h; adding menthol through a 80-120 mesh sieve, stirring for 1h; adding triethanolamine, stirring for 1h to form a gel. Make up water to 1000g to obtain the composition.

[0050] Selection of different anti-acne and antipruritic and detumescence compositions:

[0051] The formula of table 5 different anti-acne and antipruritic and detumescence composition

[0052]

[0053]

[0054] A total of 135 volunteers with mild and moderate facial acne vulgaris were selected, including 68 males and 67 females; aged 16-35 years, with an average of 24.7 years; the course of the disease was 4 weeks to 6 years, with an average of 2.8 years. Week, no use of glucocortico...

Embodiment 3

[0062] One of the extracts of honeysuckle, dandelion, sophora flavescens, and salvia miltiorrhiza was replaced with the extract of scutellaria baicalensis or purslane, which also has the effect of clearing heat and detoxifying (the extraction process is the same as that of honeysuckle extract), and the research results are as follows.

[0063] Add 10g carbopol to 700g water and soak overnight, heat at 40°C, stir for 2h; add 50g glycerin, stir for 0.5h; add 20g of 1,3-butanediol, stir for 0.5h; add honeysuckle, dandelion, flavescens, salvia miltiorrhiza, and skullcap 1. Four kinds of purslane extracts, stirred for 0.5h; added 5g of menthol passed through a 80-120 mesh sieve, stirred for 1h; added 10g of triethanolamine, stirred for 1h to form a gel. Make up water to 1000g to obtain the composition.

[0064] Screening of different alternative formulas for the composition of Table 7

[0065]

[0066] Therapeutic effect of different alternative formulas of table 8 composition ...

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Abstract

The invention discloses an anti-acne itching relieving and swelling diminishing composition and a preparation method thereof. The composition is prepared from honeysuckle flowers, herba taraxaci, radix sophorae flavescentis and radix salviae miltiorrhizae according to the mass ratio of 1.5 to 1.5 to 1 to 1. The composition provided by the invention has good compatibility with the skin; the acne can be obviously removed; the recipe can be fast absorbed by the skin; safety, no irritation and no allergy are realized. After the composition with the acne removing effect is used for 4 weeks, the skin recovers the smooth state; after stopping the use, recurrence cannot easily occur; safety and effectiveness are realized; the effect is durable. The composition gel can also be used for itching relieving and swelling diminishing after the mosquito bite; the itching is fast relieved in 10 minutes; the swelling is diminished in 2 hours; the speed of taking effect is high; safety and reliability are realized.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to an anti-acne, anti-pruritic and anti-swelling composition and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the pilosebaceous unit. It mainly occurs in adolescents. It has a great psychological and social impact on adolescents, causing patients to have negative emotions such as self-confidence, embarrassment, tension, anxiety, and depression, which affects their lives. quality. The clinical manifestations of acne are characterized by pleomorphic skin lesions such as comedones, papules, pustules, and nodules that are prone to occur on the face, occasionally accompanied by skin itching. Currently on the market, it is mainly treated with chemical bactericides, antibiotics and hormone substances. Long-term use is irritating to the skin and has great side effects. [0003] Mosquitoes are a class of very sma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K36/537A61K47/32A61P17/04A61P29/00
CPCA61K36/288A61K36/355A61K36/489A61K36/537A61K47/32A61K2236/331A61K2236/51A61K2300/00
Inventor 林山伍明李建惠林·斯蒂文黄莉媖
Owner 成都山信药业有限公司
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