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Anti-acne itching relieving and swelling diminishing composition and preparation method thereof

A technology of antipruritic and anti-swelling composition, which is applied in the field of biomedicine, can solve problems such as unsatisfactory effect, difficulty in quickly anti-itching and anti-swelling, unsuitable for people with sensitive skin, and achieve high cure rate, anti-inflammatory and anti-inflammatory effects. The effect of itching treatment

Active Publication Date: 2018-05-22
成都山信药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In general, soap or baking soda can be used to dilute and apply locally to relieve symptoms, but the effect is not ideal, and it is difficult to achieve the effect of quickly relieving itching and reducing swelling
For the antipruritic and swelling after mosquito bites, the antipruritic medicines on the market are mainly essential oils and cool oils, which contain alcohol and are not suitable for people with sensitive skin. As for hormone drugs, the antipruritic effect is very obvious, but pregnant women Children and other special populations need to be used with caution

Method used

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  • Anti-acne itching relieving and swelling diminishing composition and preparation method thereof
  • Anti-acne itching relieving and swelling diminishing composition and preparation method thereof
  • Anti-acne itching relieving and swelling diminishing composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Extraction process screening of extracts of honeysuckle, dandelion, sophora flavescens and salvia miltiorrhiza:

[0023] Extraction method of honeysuckle extract: soak the honeysuckle medicinal material with 5-15 times water for 12h; extract the medicinal material mixture at 70-90℃ for 0.5-2h, filter to obtain the extract; concentrate the extract at 60℃ to 1:1.25 (g:ml) , Cool to 35~45℃ to obtain honeysuckle extract.

[0024] Dandelion extract extraction method: pulverize the dandelion medicinal material to less than 2.0cm, add 5-15 times of water to soak for 12h; extract the medicinal material mixture at 70-90℃ for 0.5-2h, filter to obtain the extract; concentrate the extract at 60℃ to 1: 1.25 (g:ml), cool to 35~45°C to obtain dandelion extract.

[0025] Sophora flavescens extract extraction method: pulverize the dandelion medicinal material to below 2.0cm, add 5-15 times of water to soak for 12h; extract the medicinal material mixture at 70~90℃ for 0.5~2h, filter to obtain ...

Embodiment 2

[0049] The preparation method of the anti-acne, anti-itch and anti-swelling composition: soak in carbo overnight, heat at 40°C, and stir for 2 hours; add glycerin and stir for 0.5 hours; add 1,3-butanediol and stir for 0.5 hours; add the extracted honeysuckle , Dandelion, sophora flavescens, salvia miltiorrhiza extract, stir for 0.5h; add 80-120 mesh menthol, stir for 1h; add triethanolamine, stir for 1h to form a gel. Make up the water to 1000g to get the composition.

[0050] Selection of different anti-acne and anti-itch and anti-swelling compositions:

[0051] Table 5 Formulas of different anti-acne and anti-itch and anti-swelling compositions

[0052]

[0053]

[0054] A total of 135 volunteers with mild to moderate facial acne vulgaris were selected, of which 68 were males and 67 were females; aged 16-35 years old, with an average of 24.7 years; the duration of illness was 4 weeks-6 years, with an average of 2.8 years, 2 before applying the sample Zhou, never used glucocortic...

Embodiment 3

[0062] One of the extracts of honeysuckle, dandelion, sophora flavescens, and salvia miltiorrhiza was replaced with an extract of Scutellaria baicalensis Georgi or Portulaca oleracea (the extraction process is the same as the extract of honeysuckle) which also has heat-clearing and detoxifying effects. The research results are as follows.

[0063] Add 10g carbo to 700g water and soak overnight, heat at 40℃ and stir for 2h; add 50g glycerin and stir for 0.5h; add 20g of 1,3-butanediol and stir for 0.5h; add honeysuckle, dandelion, sophora flavescens, salvia miltiorrhiza, scutellaria , 4 kinds of purslane extracts, stir for 0.5h; add 5g of menthol passed through 80-120 mesh, stir for 1h; add 10g of triethanolamine, stir for 1h to form a gel. Make up the water to 1000g to get the composition.

[0064] Table 7 Screening of different alternative formulations of the composition

[0065]

[0066] Table 8 The therapeutic effect of different alternative formulations of the composition

[0067...

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Abstract

The invention discloses an anti-acne itching relieving and swelling diminishing composition and a preparation method thereof. The composition is prepared from honeysuckle flowers, herba taraxaci, radix sophorae flavescentis and radix salviae miltiorrhizae according to the mass ratio of 1.5 to 1.5 to 1 to 1. The composition provided by the invention has good compatibility with the skin; the acne can be obviously removed; the recipe can be fast absorbed by the skin; safety, no irritation and no allergy are realized. After the composition with the acne removing effect is used for 4 weeks, the skin recovers the smooth state; after stopping the use, recurrence cannot easily occur; safety and effectiveness are realized; the effect is durable. The composition gel can also be used for itching relieving and swelling diminishing after the mosquito bite; the itching is fast relieved in 10 minutes; the swelling is diminished in 2 hours; the speed of taking effect is high; safety and reliability are realized.

Description

Technical field [0001] The invention belongs to the technical field of biomedicine, and specifically relates to an anti-acne, anti-itch and anti-swelling composition and a preparation method thereof. Background technique [0002] Acne is a chronic inflammatory skin disease of the hair follicle sebaceous gland unit. It mainly occurs in adolescents. It has a great impact on the psychology and social life of adolescents. It makes the patient feel unconfident, embarrassed, nervous, anxiety, depression and other negative emotions, thereby affecting life quality. The clinical manifestations of acne are characterized by pleomorphic skin lesions such as acne, papules, pustules, and nodules that occur on the face, sometimes accompanied by skin itching. At present, the market is mainly treated with chemical fungicides, antibiotics and hormones. Long-term use is irritating to the skin and has serious side effects. [0003] Mosquitoes are very small insects with a wide variety of species. Th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K47/32A61P17/10A61P17/04A61P29/00
CPCA61K36/288A61K36/355A61K36/489A61K36/537A61K47/32A61K2236/331A61K2236/51A61K2300/00
Inventor 林山伍明李建惠林·斯蒂文黄莉媖
Owner 成都山信药业有限公司
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