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Dendritic polymer modified magnetic microspheres with uniform particle size and its preparation method and application

A dendritic and macromolecular technology, applied in the field of magnetic microspheres and their preparation, can solve the problems of uneven particle size, time-consuming, and many steps, and achieves good dispersibility and stability, great application prospects, and uniform particle size. Effect

Active Publication Date: 2020-05-26
JIANGSU ACAD OF AGRI SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The preparation method of dendrimer-modified magnetic microspheres has been reported [CN101955231B, CN103157447B], but the post-modification method is usually adopted, which has many steps and takes a long time
[0004] CN102092795A reports a method for preparing organic polymer modified iron ferric oxide multistage balls, but due to its uneven particle size, its performance will be affected in specific applications, such as poor reproducibility, etc.

Method used

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  • Dendritic polymer modified magnetic microspheres with uniform particle size and its preparation method and application
  • Dendritic polymer modified magnetic microspheres with uniform particle size and its preparation method and application
  • Dendritic polymer modified magnetic microspheres with uniform particle size and its preparation method and application

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preparation example Construction

[0035] The present invention also provides a method for preparing dendritic polymer modified magnetic microspheres with uniform particle size. The method includes the following steps: S100, preparing a solution for synthesizing magnetic microspheres; S200, uniformly dispersing the dendrimer In the solution for synthesizing magnetic microspheres; S300, the mixed solution obtained in step S200 is synthesized by a hydrothermal synthesis one-pot method to dendrimer-modified magnetic microspheres. Such as figure 1 TEM image of the fourth-generation PAMAM dendrimer modified magnetic ferroferric oxide microspheres; image 3 The fourth-generation PAMAM dendrimer modified magnetic ferroferric oxide microspheres modified boric acid for adenosine extraction ( image 3 Middle 3), and the background literature Chem. Eur. J. 2006, 12, 6341. The amount of adenosine extracted by the amino functionalized magnetic microspheres prepared in the literature after modified with boric acid ( image 3 In...

Embodiment 1

[0043] Example 1: Magnetic microspheres of ferroferric oxide were obtained according to the following preparation method:

[0044] 1.0 parts by weight of ferric chloride hexahydrate, 2.0 parts by weight of anhydrous sodium acetate, 1 part by weight of fourth-generation PAMAM dendrimer, dissolved in 35.0 parts by weight of ethylene glycol solution, mixed uniformly, and transferred to hydrothermal The reaction kettle has a hydrothermal reaction temperature of 200°C. The reaction time is 6 hours. The prepared magnetic microspheres are washed 3-5 times with methanol, 3-5 times with ethanol, 3-5 times with water, and 3-5 times with ethanol. Vacuum drying at 50°C for 12 hours for later use.

[0045] Such as figure 1 As shown, figure 1 It is a transmission electron micrograph of the fourth-generation PAMAM dendrimer modified magnetic ferroferric oxide microspheres. It can be seen from the figure that its particle size is uniform, about 100nm.

[0046] figure 2 Infrared image of the four...

Embodiment 2

[0047] Example 2: Preparation of cobalt oxide magnetic microspheres:

[0048] 2.0 parts by weight of cobalt chloride hexahydrate, 10 parts by weight of anhydrous sodium acetate, 2 parts by weight of dendrimer, dissolved in 45 parts by weight of ethylene glycol solution, mixed uniformly, transferred to the hydrothermal reactor, hydrothermally The reaction temperature is 300°C. The reaction time is 8 hours. The prepared magnetic microspheres are washed 3-5 times with methanol, 3-5 times with ethanol, 3-5 times with water, and 3-5 times with ethanol. Vacuum drying at 50°C for 12 hours for later use.

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Abstract

The invention relates to dendritic polymer-modified magnetic microspheres with uniform particle sizes and a preparation method and application thereof. Through use of a dendritic polymer on the surface of a magnetic carrier, the magnetic microsphere is obtained. The magnetic carrier is a magnetic nanoparticle or a magnetic microparticle. The preparation method comprises directly dispersing the dendritic polymers in a solution for synthesis magnetic microspheres and directly synthesizing the dendritic polymer-modified magnetic microspheres through a hydrothermal synthesis one-pot method. The magnetic microspheres have the better capability of enrichment, have uniform magnetic particle sizes, are prepared through simple processes and are free of post-modification.

Description

Technical field [0001] The invention relates to the field of functionalized materials, in particular to a dendritic polymer modified magnetic microsphere with uniform particle size, and a preparation method and application thereof. Background technique [0002] Magnetic microspheres include magnetic nanoparticles and microparticles. Due to their special physical and chemical properties, they have broad application prospects in materials, biology and other fields, such as magnetic separation and magnetic targeted drug delivery. In order to adapt to different applications, a variety of modified magnetic microspheres and their composite structures are used, such as functional silicon-coated magnetic microspheres, polymer graft modified magnetic microspheres and other materials have been widely prepared And get practical application. Normally prepared functionalized magnetic microspheres have low surface group content, which requires highly sensitive detection methods for detection ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01J13/06
CPCB01J13/06
Inventor 王合叶王冉
Owner JIANGSU ACAD OF AGRI SCI
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