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Induction method of Lgr5<+> (leucine-rich repeat-containing g-protein coupled receptor 5<+>) hepatic stem cells, and application thereof in detection

A technology of liver stem cells and liver cells, applied in the field of protein biochemical induction, to achieve the effect of expanding application methods, expanding application scope, and promoting tissue damage repair/regeneration

Inactive Publication Date: 2018-05-04
SOUTHERN MEDICAL UNIVERSITY
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0010] The use of stem cells to treat chronic liver fibrosis has not been reported so far

Method used

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  • Induction method of Lgr5&lt;+&gt; (leucine-rich repeat-containing g-protein coupled receptor 5&lt;+&gt;) hepatic stem cells, and application thereof in detection
  • Induction method of Lgr5&lt;+&gt; (leucine-rich repeat-containing g-protein coupled receptor 5&lt;+&gt;) hepatic stem cells, and application thereof in detection
  • Induction method of Lgr5&lt;+&gt; (leucine-rich repeat-containing g-protein coupled receptor 5&lt;+&gt;) hepatic stem cells, and application thereof in detection

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Embodiment Construction

[0079] The present invention is described in detail below in conjunction with embodiment. In order to make the object, technical solution and advantages of the present invention clearer and clearer, the present invention will be described in further detail below with reference to the accompanying drawings and examples, but the present invention is not limited to these examples.

[0080] Unless otherwise specified, the raw materials and catalysts in the examples of the present invention were purchased through commercial channels. Among them, Lgr5 (leucine-rich repeat-containing g-protein coupled receptor5) belongs to the G protein-coupled receptor family, which contains 17 leucine-rich repeat sequences and 7 a-helix transmembrane regions, and its N- and C- The terminal tail is flanked by cysteine-rich sequences, which can be expressed in various tissues such as gastrointestinal tract and hair follicles.

[0081] The in-depth study of embryonic stem cells (ESC) and the rise of ...

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Abstract

The invention discloses an induction method of Lgr5<+> (leucine-rich repeat-containing g-protein coupled receptor 5<+>) hepatic stem cells, and application thereof in detection. According to the induction method of the Lgr5<+> hepatic stem cells, hepatic injury is recovered through induction of the Lgr5<+> hepatic stem cells by HGF and / or Rspo1; by means of self-renewal and multifunctional differentiating capacity of endogenous stem cells of tissue and organs, the endogenous stem cells of the in-vivo tissue and organs are stimulated and activated directly by soluble molecules, so that self-healing / regeneration of the tissue and the organs is promoted. It is verified that HGF and / or Rspo1 have / has an induction effect on the humanLgr5<+> hepatic stem cells.

Description

technical field [0001] The invention relates to the technical field of protein biochemical induction, in particular to a method for restoring liver function damage by inducing Lgr5-positive liver stem cells and its application. Background technique [0002] The liver is a very important vital organ of the digestive system. It is responsible for regulating many important physiological activities, including glycogen storage, lipid metabolism, plasma protein secretion, foreign substance detoxification, bile secretion, etc. [0003] Loss of liver function is so diverse and important that within days organ failure, secondary hypotension, diabetes, brain damage and even death can result. Liver diseases, such as hepatic metabolic diseases, fulminant hepatic failure, hepatitis, cirrhosis, liver cancer, etc., are an important cause of death worldwide. [0004] At present, the treatment status of liver diseases is not optimistic. Liver dialysis technology can cope with the threat of ...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61K38/17A61P1/16C12N5/071
CPCA61K38/1833A61K38/1709C12N5/067C12N2501/12C12N2501/998
Inventor 周伟杰林媛
Owner SOUTHERN MEDICAL UNIVERSITY
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