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Medicine composition for treating congestive heart-failure and tablet and preparation method thereof

A heart failure and composition technology, which is applied in the field of medicine and achieves significant clinical effects, treatment of heart failure, and effective treatment.

Inactive Publication Date: 2018-05-01
QINGDAO AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the study of combining it with benazepril hydrochloride has not been reported

Method used

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  • Medicine composition for treating congestive heart-failure and tablet and preparation method thereof
  • Medicine composition for treating congestive heart-failure and tablet and preparation method thereof

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Experimental program
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Embodiment

[0019] Weigh 23.85 mg of benazepril hydrochloride, 3.70 mg of hyaluronic acid, 46.20 mg of dextrin, 18.75 mg of magnesium stearate and 27.50 mg of 50% sodium carboxymethylcellulose, pass through a 100-mesh sieve, and 50% of carboxymethylcellulose Sodium cellulose base and dextrin are added to the internal and external parts respectively, and the weight ratio of the internal and external parts is 2:1. The internal and external parts are weighed respectively and marked;

[0020] Mix benazepril hydrochloride, hyaluronic acid and dextrin in a mixer evenly, add 50% sodium hydroxymethylcellulose, continue mixing to make a soft material, and granulate with a 30-mesh sieve;

[0021] After the granules are dried at 50°C, they are sieved with a 30-mesh sieve, and the sieved plain granules, pulverized raw materials, and some excipients are mixed evenly with magnesium stearate, and pressed into tablets with a weight of 120 mg.

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PUM

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Abstract

The invention discloses a medicine composition for treating congestive heart-failure and a tablet and a preparation method thereof. The medicine composition is prepared from the following two components of benazepril hydrochloride and hyaluronic acid; the tablet is prepared from the medicine composition and auxiliary materials by a powder tabletting technology. The medicine composition has the advantages that the benazepril hydrochloride and the hyaluronic acid are jointly used, so that the effect of treating the congestive heart-failure of pet is better, the synergistic function is realized,and the angiotensin converting enzyme can be quickly and well inhibited; the concentration of angiotensin converting in blood plasma is quickly decreased, and the function of treating the heart failure, hypertension and the like is realized; the clinical effect is obvious, the adverse reaction is little, and the effect of treating the heart disease of the pet is effective.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a pharmaceutical composition for treating congestive heart failure, a tablet and a preparation method thereof. Background technique [0002] With the development of my country's social economy and the acceleration of urbanization, the upsurge of pet breeding is booming in my country's cities, and my country's pet industry has gradually entered the aging process. In recent years, canine cardiovascular and cerebrovascular diseases have gradually increased in pet clinics. According to an epidemiological survey in a veterinary hospital in the United States, the incidence rate of heart disease in dogs is very high, which can reach 10%. The level of treatment of vascular system diseases is still unsatisfactory, and it is still in its infancy, most of which are mainly for the treatment of heart failure. In view of the increasingly prominent cardiovascular and cerebrovascular diseas...

Claims

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Application Information

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IPC IPC(8): A61K31/728A61K31/55A61K9/20A61P9/04A61P9/12
Inventor 单虎秦志华张慧郭沛
Owner QINGDAO AGRI UNIV
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