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Method for improving water solubility of acetylisovaleryltylosin tartrate

A technology of acetylisovaleryl tylosin tartrate and acetyl isovaleryl tylosin, applied in chemical instruments and methods, preparation of sugar derivatives, sugar derivatives, etc. Isovaleryl tylosin can not be completely dissolved and other problems, to achieve the effect of high yield, good water solubility and low cost

Active Publication Date: 2018-04-20
湖北回盛生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of separation and purification directly affects the quality of the final product. Under the existing process conditions, acetylisovaleryl tylosin tartrate cannot be completely dissolved in tap water, which brings great inconvenience to pharmaceutical preparations and applications.

Method used

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  • Method for improving water solubility of acetylisovaleryltylosin tartrate
  • Method for improving water solubility of acetylisovaleryltylosin tartrate
  • Method for improving water solubility of acetylisovaleryltylosin tartrate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A method for improving the water solubility of acetylisovaleryl tylosin tartrate, the steps are as follows:

[0037] (1) Take 100g of the crude extract of acetylisovaleryl tylosin, add 200ml of purified water, fully stir and disperse with a magnetic stirrer, and control the temperature at 30°C. After washing, use suction filtration to separate the solid from the liquid and collect the solid ;

[0038] (2) Disperse the collected solids again with 200ml of purified water by magnetic stirring, while controlling the temperature at 30°C. After washing, separate the solids and liquids by suction filtration, and collect the washed acetylisovaleryl tylosin;

[0039] (3) Add a little purified water to the washed acetylisovaleryl tylosin, cool down to 10°C, gradually add food grade L-tartaric acid to adjust the pH to 3.0, liquid phase detection and control of acetylisovaleryl tylosin The concentration of mycocin is 200000ppm;

[0040] (4) Add polyaluminum chloride with a soluti...

Embodiment 2

[0048] A method for improving the water solubility of acetylisovaleryl tylosin tartrate, the steps are as follows:

[0049] (1) Take 100g of the crude extract of acetylisovaleryl tylosin, add 350ml of purified water, fully stir and disperse with a magnetic stirrer, and control the temperature at 40°C. After washing, use suction filtration to separate the solid from the liquid, and collect the solid ;

[0050] (2) Magnetically stir and disperse the collected solids with 350ml of purified water again, while controlling the temperature at 40°C. After washing, separate the solids and liquids by suction filtration, and collect the washed acetylisovaleryl tylosin;

[0051] (3) Add a little purified water to the washed acetylisovaleryl tylosin, and cool down to 15°C, gradually add food grade L-tartaric acid to adjust the pH to 4.0, liquid phase detection and control of acetylisovaleryl tylosin The concentration of mycocin is 200000ppm;

[0052](4) Add polyaluminum chloride with a s...

Embodiment 3

[0060] A method for improving the water solubility of acetylisovaleryl tylosin tartrate, the steps are as follows:

[0061] (1) Take 100g of the crude extract of acetylisovaleryl tylosin, add 500ml of purified water, fully stir and disperse with a magnetic stirrer, and control the temperature at 50°C. After washing, use suction filtration to separate the solid from the liquid, and collect the solid ;

[0062] (2) Magnetically stir and disperse the collected solids with 500ml of purified water again, while controlling the temperature at 50°C. After washing, separate the solids and liquids by suction filtration, and collect the washed acetylisovaleryl tylosin;

[0063] (3) Add a little purified water to the washed acetylisovaleryl tylosin, cool down to 20°C, gradually add food grade L-tartaric acid to adjust the pH to 5.0, liquid phase detection and control of acetylisovaleryl tylosin The concentration of mycocin is 200000ppm;

[0064] (4) Add polyaluminium chloride with a sol...

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Abstract

The invention provides a technical method for improving the water solubility of acetylisovaleryltylosin tartrate through extraction, purification and impurity removal. The method comprises the following steps: firstly stirring and washing an acetylisovaleryltylosin crude extract with purified water, heating the crude extract to 30 to 50 DEG C while stirring is performed, and filtering, so as to obtain an acetylisovaleryltylosin washed product, repeating the step again, and ensuring that the yield of the crude extract is greater than 99 percent after two times of purification and washing; thendissolving the acetylisovaleryltylosin washed product with purified water, adding tartaric acid while dissolving is performed, to adjust the pH to be 3 to 5, cooling the washed product to 10 to 20 DEGC, adding aluminum polychlorid after the washed product is completely dissolved, ensuring that a small amount of precipitate appears, and performing solid-liquid separation through a decolorizing agent after the washed product is left to stand, so as to obtain clear and transparent bright yellow solution; and finally performing drying and water removal, so as to obtain an acetylisovaleryltylosintartrate finished product, and ensuring that the finished product is clear and transparent faint yellow after the finished product is dissolved in tap water.

Description

technical field [0001] The invention belongs to the technical field of extraction and purification after antibiotics are produced by fermentation, and in particular relates to a process method for extracting, purifying, and removing impurities of acetylisovaleryl tylosin tartrate to improve its water solubility. Background technique [0002] Acetylisovaleryl Tylosin is an upgraded substitute product of Tylosin drugs widely used at home and abroad. As a new type of antibacterial drug, acetylisovaleryl tylosin is characterized by a wider antibacterial spectrum (special effect on tylosin-resistant bacteria) and higher antibacterial activity (activity is 3 times that of tylosin). -10 times), the dosage is small and the residue is low. It has a new molecular structure, bacteria are not easy to develop resistance to it, and it does not produce cross-resistance to antibiotics with similar chemical structures. Acetylisovaleryl Tylosin can be used to treat livestock and poultry dis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/08C07H1/06
CPCC07H1/06C07H17/08
Inventor 戴军康远军高经纬郝康刘勇斌周泉刘洁
Owner 湖北回盛生物科技有限公司
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