Iodine-containing polycarbonate/polyester material for X-ray development and preparation method and application thereof

Abstract

The invention belongs to the field of biomedical polymer materials, and particularly relates to an iodine-containing polycarbonate / polyester polymer for X-ray development and a preparation method andapplication thereof. The iodine-containing polycarbonate / polyester polymer disclosed by the invention has excellent X-ray radiopacity or property of weakening X-rays. Under the existence of a catalyst, with a small-molecule hydroxyl compound as an initiator, through the ring-opening homopolymerization of an iodine-containing carbonate monomer or the ring-opening copolymerization of the iodine-containing carbonate monomer and other lactone, lactide and / or carbonate monomers, the iodine-containing polycarbonate / polyester material is obtained. The iodine-containing polycarbonate / polyester polymercan be applied in fields such as visualized embolization materials, anti-counterfeit labels, contrast media, antibacterial materials, prevention or treatment of iodine deficiency disorders, flame-retardant materials, tissue engineering and drug delivery systems.

Description

technical field [0001] The invention belongs to the field of biomedical polymer materials, and in particular relates to an iodine-containing polycarbonate / polyester polymer with X-ray imaging function and its preparation method and application. Background technique [0002] Biomedical polymer materials have many advantages such as good biocompatibility and easy-to-adjust degradability, and are an important content of biomedical material research. They have broad application prospects in the fields of medical imaging, tissue engineering, and drug delivery systems. . Among them, degradable polycarbonate / polyester material is one of the most widely used medical degradable polymer materials. At present, many products and devices based on such materials have been approved by the FDA and widely used in clinical practice. However, due to the complex physiological environment in the body, it is still difficult to conveniently and accurately evaluate the degradation behavior of suc...

AI Technical Summary

Problems solved by technology

However, the preparation conditions of such a monomer itself are relatively harsh, requiring a low temperature of -80°C; at the same time, the direct introduction of iodine atoms at the α position makes its structure unstable for two reasons: 1) due to the electron-withdrawing effect of the adjacent carbonyl group , making it easy to undergo nucleophilic substitution at the α position, and the iodine atom itself is a good leaving group; 2) The iodo product at the α position of the carbonyl group is also prone to elimination reactions, resulting in more stable α, β-unsaturated lactones ; These factors all cause this iodine-containing monomer to decompose easily, and it is difficult to store for a long time

Even short-term storage requires very harsh storage conditions: dark storage at -15°C, this shortcoming greatly limits its practical application

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