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Calcium silicate lithium-system novel biological activity ceramic support and preparation method and purpose thereof

A technology of bioactive ceramics and calcium-lithium silicate, which is applied in prosthesis, tissue regeneration, medical science, etc., can solve the problem of insufficient cartilage regeneration ability, and achieve good dual bioactivity, good repair, and easy control of conditions

Active Publication Date: 2018-04-06
SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] The calcium-lithium silicate system bioactive ceramic scaffold of the present invention has good degradability, mechanical properties and biological activity, and has good dual biological activities, and can simultaneously promote osteogenesis and chondrogenic differentiation of bone marrow mesenchymal stem cells and chondrocytes And bone-cartilage integrated repair in vivo, it is expected to solve the problem of insufficient cartilage regeneration ability in bone-cartilage integrated repair, and achieve good repair of large-area cartilage defects

Method used

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  • Calcium silicate lithium-system novel biological activity ceramic support and preparation method and purpose thereof
  • Calcium silicate lithium-system novel biological activity ceramic support and preparation method and purpose thereof
  • Calcium silicate lithium-system novel biological activity ceramic support and preparation method and purpose thereof

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Effect test

Embodiment 1

[0092] Preparation of Li by sol-gel method 2 Ca 4 Si 4 o 13 bioactive ceramic scaffold

[0093] (1) Tetraethyl orthosilicate, deionized water and 2mol L -1 The nitric acid was mixed and stirred at a molar ratio of 1:8:0.08 for 0.5h to completely hydrolyze. According to the stoichiometric ratio Li:Ca:Si=2:4:4, lithium nitrate and calcium nitrate were added in sequence, and stirred for 5 hours to obtain a clear solution. Then the obtained clear solution was sealed in an oven at 60°C for 24 hours and dried at 120°C for 72 hours to obtain a xerogel; the xerogel was ball-milled for 6 hours and sieved, calcined at 940°C for 3 hours, and cooled naturally to obtain Li 2 Ca 4 Si 4 o 13 For bioactive ceramic powder, its XRD pattern can be found in figure 1 , it can be seen that it is a pure phase;

[0094] (2) Li will be obtained 2 Ca 4 Si 4 o 13 Bioactive ceramic powder: sodium alginate: F127 was mixed at a mass ratio of 1:0.06:0.8, and the printing program was designed ...

Embodiment 2

[0097] Preparation of Li by sol-gel method 2 Ca 2 Si 2 o 7 bioactive ceramic scaffold

[0098] (1) Tetraethyl orthosilicate, deionized water and 3mol L -1 The nitric acid was mixed and stirred at a molar ratio of 1:9:0.06 for 1 hour to completely hydrolyze. According to the stoichiometric ratio Li:Ca:Si=2:2:2, lithium nitrate and calcium nitrate were added in sequence, and stirred for 5 hours to obtain a clear solution. Then the obtained clear solution was sealed in an oven at 50°C for 36 hours and dried at 120°C for 60 hours to obtain a xerogel; the xerogel was ball-milled for 5 hours and sieved, calcined at 850°C for 2 hours, and cooled naturally to obtain Li 2 Ca 2 Si 2 o 7 For bioactive ceramic powder, its XRD pattern can be found in Figure 9 , it can be seen that it is a pure phase;

[0099] (2) Li will be obtained 2 Ca 2 Si 2 o 7Bioactive ceramic powder: sodium alginate: F127 was mixed at a mass ratio of 1:0.08:1.0, and the printing program was designed u...

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Abstract

The invention relates to a calcium silicate lithium-system novel biological activity ceramic support and a preparation method and a purpose thereof. The calcium silicate lithium-system novel biological activity ceramic support is a three-dimensional porous support, and a chemical composition is LixCaySizOn, wherein x+2y+4z=2n. The calcium silicate lithium-system novel biological activity ceramic support has good degradability, mechanical properties and biological activity, has good bibiological activity, and can promote ossification and chondrogenic differentiation of mesenchymal stem cells and cartilage cells as well as in-vivo bone-cartilage integrated restoration.

Description

technical field [0001] The invention relates to the repair of osteochondral defect, in particular to a novel bioactive ceramic support of calcium-lithium silicate system, its preparation method and its application in the repair of osteochondral defect, belonging to the field of biomaterials. Background technique [0002] Osteochondral injury caused by trauma, osteoarthritis, etc. is a very common clinical disease, and it is a recognized treatment problem in orthopedics and sports medicine. This is because articular cartilage is a kind of avascular and nerveless connective tissue with slow cell metabolism. Once it is damaged, its spontaneous repair and regeneration ability is very poor[1]. At present, the main methods for the clinical treatment of cartilage injuries include bone marrow stimulation, microfracture, auto / allogeneic osteochondral transplantation, auto / allogeneic chondrocyte transplantation, etc. [2], but these methods have limitations [3]. More and more studies ...

Claims

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Application Information

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IPC IPC(8): A61L27/10A61L27/56A61L27/58A61L27/50
CPCA61L27/10A61L27/50A61L27/56A61L27/58A61L2430/06
Inventor 吴成铁陈蕾邓翠君常江
Owner SHANGHAI INST OF CERAMIC CHEM & TECH CHINESE ACAD OF SCI
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