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Preparation method of carrier free nano drug for chemotherapy/light treatment

A nano-drug, carrier-free technology, applied in the field of preparation of carrier-free nano-drugs, can solve the problems of unclear mechanism of action of artificially synthesized carriers, slow growth, and inability to effectively inhibit metabolic tumors in vivo, and achieve good chemotherapy and phototherapy effects. , the effect of increasing lethality, good imaging effect

Active Publication Date: 2018-04-06
FUZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the present invention, the co-assembled carrier-free nano-medicine with the integrated functions of chemotherapy and phototherapy formed by π-π stacking, hydrophobicity and electrostatic force solves the problem of unclear mechanism of action of artificially synthesized carriers in the prior art, in vivo metabolism and most tumors in a single Problems that cannot be effectively suppressed or still grow slowly under treatment methods

Method used

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  • Preparation method of carrier free nano drug for chemotherapy/light treatment
  • Preparation method of carrier free nano drug for chemotherapy/light treatment
  • Preparation method of carrier free nano drug for chemotherapy/light treatment

Examples

Experimental program
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Effect test

Embodiment 1

[0050] The preparation method of ursolic acid nano micelles

[0051] Accurately weigh 0.00456g of UA powder, dissolve it in 1ml of methanol, dissolve it ultrasonically, and prepare a 10 mM ursolic acid methanol solution; take 10 µL of LUA methanol solution, and add it dropwise to a container containing 1000 µL of secondary water (double-distilled water). In the EP tube (note: vortex during the dropping process), after ultrasonication for 10 minutes, dry the methanol to obtain UA nanomicelle;

[0052] The average particle diameter of the UA nanomicelle prepared in this embodiment is about 86.55nm nanometers, and the particle diameter diagram is as follows figure 1 shown.

Embodiment 2

[0054] Accurately weigh 0.00456g of UA powder, dissolve it in 1ml of methanol, and dissolve it ultrasonically to prepare a 10 mM methanol solution of ursolic acid; accurately weigh 0.00356g of lactobionic acid powder, dissolve it in 1ml of secondary water, and dissolve it ultrasonically to prepare 10 mM lactobionic acid aqueous solution.

[0055] Take 5 µLLA aqueous solution and add it dropwise to the EP tube filled with 995 µL double-distilled water, then take 10 µLUA methanol solution and add it dropwise to the EP tube (Note: Vortex during the dropping process), after ultrasonication for 10 min, Blow dry methanol to obtain UA-LA nano-medicine;

[0056] The average particle size of UA-LA nanomedicine prepared in this example is about 99.88nm, and the particle size diagram is as follows figure 2 shown.

Embodiment 3

[0058] Accurately weigh 0.00456g of UA powder, dissolve it in 1ml of methanol, and ultrasonically dissolve it to prepare a 10 mM ursolic acid methanol solution; accurately weigh 0.00774g of indocyanine green powder, dissolve it in 1ml of methanol, and ultrasonically dissolve it to prepare 10 mM indocyanine green in methanol.

[0059] Take 2.5 µL ICG methanol solution and add it dropwise to the EP tube filled with 1000 µL redistilled water, then take 10 µL LUA methanol solution and add it dropwise to the EP tube (note: vortex during the dropping process), after ultrasonication for 10 min , drying methanol to obtain UA-ICG nano-medicine;

[0060] The average particle size of UA-ICG nanomedicine prepared in this example is about 105.1nm, and the particle size diagram is as follows image 3 shown.

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Abstract

The invention provides a preparation method of a carrier free nano drug for chemotherapy / light treatment. The drug is prepared by assembling a hydrophobic anticancer drug, a water soluble target, andan amphipathic photosensitizer through a self-assembly technology. The assembled carrier free nano drug is formed through phi-phi accumulation, hydrophobic force, and electrostatic force, is used forchemotherapy and light treatment, and solves the problems that in the prior art, the action mechanism of an artificially synthesized carrier is undefined, and metabolism and most of tumors cannot be inhibited effectively by a single treatment method and still grows slowly.

Description

technical field [0001] The invention relates to the field of tumor diagnosis and treatment integration, and relates to a preparation method of a carrier-free nano drug co-assembled with a chemotherapeutic drug and a photosensitizer. Background technique [0002] Cancer is a devastating disease that is now one of the most common causes of death around the world. Current tumor treatment methods mainly include: chemotherapy, surgical resection, radiotherapy, photodynamic therapy, gene therapy and so on. However, most tumors are not effectively suppressed or still grow slowly under monotherapy such as chemotherapy alone. At present, tumor synergistic therapy has good therapeutic effect and has attracted extensive attention of researchers. In recent years, the rapid development of nanobiotechnology has brought new opportunities for cancer treatment. Compared with traditional chemotherapeutic drugs, a variety of nano-drug delivery systems developed on the basis of nanotechnolog...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P35/00A61K41/00A61K47/26A61K9/107A61K9/51
CPCA61K9/1075A61K9/5123A61K31/56A61K41/0057A61K47/26A61K2300/00
Inventor 邵敬伟赵瑞瑞郭燕沈志春
Owner FUZHOU UNIVERSITY
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