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A kind of composite antioxidant self-microemulsion and its preparation method and application

A composite antioxidant, self-microemulsion technology, applied in the application, cosmetic preparations, antidote and other directions, can solve the problem of lack of antioxidant activity, such as the antioxidant capacity, to achieve good antioxidant effect, uniform distribution, small particle size Effect

Active Publication Date: 2021-01-26
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, for antioxidant active substances with low solubility or easy to change color at room temperature, most of them are prepared from microemulsions with a single active ingredient. Although the problem of solubility is solved, it does not have the antioxidant capacity of volatile antioxidant active substances to the greatest extent.

Method used

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  • A kind of composite antioxidant self-microemulsion and its preparation method and application
  • A kind of composite antioxidant self-microemulsion and its preparation method and application
  • A kind of composite antioxidant self-microemulsion and its preparation method and application

Examples

Experimental program
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Effect test

Embodiment 1

[0050] Add 5.6g IPM, 26.64g PEG-40 hydrogenated castor oil, and 17.76g propylene glycol to the reactor once and stir for 2 minutes to prepare a blank self-microemulsion. Add 1g ferulic acid, 1g resveratrol, and 2g vitamin E to the blank self-microemulsion middle. Stir at room temperature 25°C for 20 minutes to obtain a clear and transparent composite antioxidant self-microemulsion.

[0051] Taking Example 1 as an example, measure the self-microemulsion stability under the proportioning ratio, take an appropriate amount of self-microemulsion and place it under high temperature (45° C.) conditions for 3 months, and use Zetasizer-nano-zs90 particle size analyzer to measure its particle size. The results are shown in Table 1 and figure 1 and figure 2 . Notes in the figure: size represents the particle size of self-microemulsion, and Intensity represents the distribution concentration (%) of self-microemulsion particles.

[0052] Table 1 Self-microemulsion particle size

[0...

Embodiment 2

[0056] Add 1.12g of isopropyl palmitate, 5.328g of Tween-80, and 3.552g of propylene glycol at one time into the reactor to obtain a clear and transparent blank self-microemulsion. Take 0.1g of ferulic acid, 0.1g of resveratrol, and 0.3g of vitamin E was added to the blank self-microemulsion, and stirred at room temperature at 25°C for 20 minutes to obtain a clear and transparent composite antioxidant self-microemulsion. After testing, the particle size of the self-microemulsion is 21.68nm. The self-microemulsion is still clear and transparent after being placed under the high temperature condition of 45°C for 3 months.

Embodiment 3

[0058] Add 1.68g octyldodecanol, 7.992g PEG-60, and 5.382g glycerin to the reactor at one time to obtain a clear and transparent blank self-microemulsion, take 0.2g ferulic acid, 0.2g resveratrol, and 0.2g vitamin E, stirring at room temperature 25°C for 20 minutes to obtain a clear and transparent composite antioxidant self-microemulsion. After testing, the particle size of the self-microemulsion is 23.27nm. The self-microemulsion is still clear and transparent after being placed under the high temperature condition of 45°C for 3 months.

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Abstract

The invention discloses a composite antioxidant self-microemulsion as well as a preparation method and application of the microemulsion, belonging to the field of preparations. The composite antioxidant self-microemulsion contains the following components in percentage by weight: 1%-4% of an oil phase, 10%-60% of a surfactant, 2%-50% of a cosurfactant and 1%-20% of a compound antioxidant, whereinthe compound antioxidant is a mixture of vitamin E, ferulic acid and resveratrol. Vitamin E, ferulic acid and resveratrol have different antioxidant mechanisms, are mutually complemented and repairedand are compounded, so that an anti-oxidation synergistic interaction effect can be achieved. By optimizing a self-microemulsion system, a proper oil phase, a proper mixed surfactant and a proper cosurfactant are screened and are utilized for dissolving vitamin E, ferulic acid and resveratrol in the compound antioxidant; and by regulating the proportion of the self-microemulsion system, the microemulsion with a particle size smaller than 70nm is obtained, the functional components of the microemulsion can be easily transdermally absorbed, and a very good anti-oxidation effect is achieved.

Description

technical field [0001] The invention belongs to the field of preparations, and in particular relates to a composite anti-oxidation self-microemulsion and its preparation method and application. Background technique [0002] Antioxidants are a class of substances that can react with active oxygen and prevent oxidation reactions, and are widely used in the fields of food, medicine, hygiene and cosmetics. With the continuous improvement of people's living standards and health awareness, natural antioxidants are more and more favored by people. Generally, high-efficiency antioxidant factors come from natural polyphenols, but polyphenols are easily oxidized and inactivated in contact with air under normal conditions, and their stability is poor, so it is difficult to achieve the ideal antioxidant effect. [0003] Resveratrol is one of the active ingredients of peanuts, grapes, and mulberries. It belongs to polyphenols and has a strong antioxidant effect. It can improve skin qual...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/67A61K8/36A61K8/34A61K8/06A61Q19/08A61K9/107A61K31/355A61K31/192A61K31/05A61K47/14A61K47/44A61K47/10A61P39/06A23L33/15A23L33/105
CPCA23V2002/00A61K8/068A61K8/347A61K8/36A61K8/678A61K9/1075A61K31/05A61K31/192A61K31/355A61K47/10A61K47/14A61K47/44A61K2800/522A61Q19/08A23L33/105A23L33/15A61K2300/00A23V2200/30A23V2250/712A23V2250/02A23V2250/2132A23V2250/21
Inventor 吴培诚王卓娅刘彩云罗欣茹廖翠琴
Owner GUANGDONG PHARMA UNIV
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