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Nerve regulating and controlling method and device

A technology for regulating devices and nerves, applied in the field of medical equipment

Pending Publication Date: 2018-03-30
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present application provides a neuromodulation method and device to solve the deficiencies of neuromodulation devices in the prior art

Method used

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  • Nerve regulating and controlling method and device
  • Nerve regulating and controlling method and device
  • Nerve regulating and controlling method and device

Examples

Experimental program
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Embodiment Construction

[0038] Such as figure 1 as shown, figure 1 It shows a schematic structural diagram of a neuromodulation device provided by the present application, such as figure 1 As shown, the device includes: a brain slice fixing device 101, an isolated live brain slice is fixed in the brain slice fixing device 101, and the brain slice fixing device 101 is filled with circulating cerebrospinal fluid meeting a preset temperature, and A cerebrospinal fluid circuit is formed in the brain slice fixation device 101; wherein, the isolated living brain slice is obtained by transfecting the brain region of interest to the recipient according to a preset method; the electrical stimulation device 102 is an electrical stimulation device 102 is connected with the brain slice fixing device 101 and is used for stimulating the isolated living brain slice in the brain slice fixing device 101 .

[0039] The acquisition device 103 is used to collect the changes in cell behavior and morphology of the lenti...

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Abstract

The invention provides a nerve regulating and controlling method and a nerve regulating and controlling device, and relates to the technical field of medical equipment. The nerve regulating and controlling device is used for overcoming the defects of the nerve regulating and controlling device in the prior art, and comprises a brain slice fixing device, an electric stimulation device and a collecting device, wherein an in-vitro live brain slice is fixed in the brain slice fixing device; the brain slice fixing device is filled with circulating cerebrospinal fluid meeting the preset temperature,and a cerebrospinal fluid loop is formed in the brain slice fixing device; the in-vitro live brain slice is obtained by transfecting a brain area interested in a receptor and according to a preset mode; the electric stimulation device is connected with the brain slice fixing device and is used for applying stimulation to the in-vitro live brain slice in the brain slice fixing device; and the collecting device is used for showing the ethological and morphological change of a lentivirus transfection marked cell or the change of ions in an organelle and a cytoplasma of a cell in real time in theprocess of applying stimulation to the in-vitro live brain slice by the electric stimulation device.

Description

technical field [0001] The present application relates to the technical field of medical devices, in particular to a neuromodulation method and device. Background technique [0002] As the effectiveness and safety of physical factors in the treatment of central nervous system diseases are gradually confirmed, the breadth and depth of research in this area are constantly expanding. Among them, the non-invasive neuromodulation technology represented by electrical stimulation and magnetic Progress has been made in research. However, due to the limitations of research methods, basic research mainly focuses on computer simulation of biological effects or the use of molecular biology to study molecular signaling pathways related to neural regulation. However, this form of research is due to the specificity of the brain structure of biological individuals. The sensitivity is so large that the simulation results are difficult to reproduce in biological individuals. On the other han...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/42C12M1/36C12M1/34C12N13/00C12Q1/02
CPCG01N33/5005C12N13/00
Inventor 丁桂荣张克英安广洲周艳林加金
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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