3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application

A tracheal stent, 3D printing technology, applied in the field of medical devices, to achieve the effects of reducing the incidence of infection, fast degradation, and solving construction difficulties

Pending Publication Date: 2018-03-30
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, there is no report about the 3D printed incomplete tracheal ring of the present invention that can be embedded in a double-layer PLLA tissue engineering tracheal stent and its application

Method used

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  • 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application
  • 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application
  • 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application

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Experimental program
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Embodiment 1

[0035] Please refer to the attached figure 1 , attached figure 2 , attached image 3 , attached Figure 4 , attached Figure 5 , with figure 1 , 4 It is a structural schematic diagram of a 3D printed incomplete tracheal ring that can be embedded in a double-layer PLLA tissue engineering tracheal stent and its application in this embodiment. figure 2 It is a 3D printed non-complete tracheal ring embeddable double-layer PLLA tissue engineering tracheal stent of this embodiment and a schematic structural diagram of a degradable tracheal stent with an incomplete tracheal ring PLLA on its outer layer, attached image 3 It is a 3D printed incomplete tracheal ring embeddable double-layer PLLA tissue engineering tracheal stent of this embodiment and a schematic structural diagram of a PLLA degradable tracheal stent with no incomplete tracheal ring in the inner layer, attached Figure 5 It is a top view of a 3D printed incomplete tracheal ring embeddable double-layer PLLA tissu...

Embodiment 2

[0045] Please refer to the attached figure 1 , attached Figure 5 , with figure 1 It is a structural schematic diagram of a 3D printed incomplete tracheal ring that can be embedded in a double-layer PLLA tissue engineering tracheal stent and its application in this embodiment. Figure 5 It is a top view of a 3D printed incomplete tracheal ring embeddable double-layer PLLA tissue engineering tracheal stent and its application in this embodiment.

[0046] The 3D printed incomplete tracheal ring can be embedded in a double-layer PLLA tissue engineering tracheal stent and its application method:

[0047] First, the PLLA degradable tracheal stent (100) with an incomplete tracheal ring on the outer layer and the PLLA degradable tracheal stent (200) without an incomplete tracheal ring on the inner layer are respectively constructed by 3D printing technology; The PLLA degradable tracheal stent (100) with an incomplete tracheal ring is an integrally formed structure printed by 3D pr...

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Abstract

The invention relates to a 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent and its application. The 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent comprises a PLLA degradable tracheal stent of which outer layer is provided with an incomplete tracheal ring, and a PLLA degradable tracheal stent of which inner layer is free from the incomplete tracheal ring; the PLLA degradable tracheal stent of which outer layer is provided with the incomplete tracheal ring is composed of an outer layer PLLA degradable tracheal stent and an incomplete tracheal ring; the side face of the outer layer PLLA degradable tracheal stent is provided with a bracket notch penetrated through the pipe wall and several incomplete tracheal rings; one penetrated tracheal ring notch is arranged on the incomplete tracheal ring; the PLLA degradable tracheal stent of which inner layer is free from the incomplete tracheal ring is embedded in the pipe of the PLLA degradable tracheal stent of which outer layer is provided with the incomplete tracheal ring. The 3D printing incomplete tracheal ring embeddable double-layered PLLA tissue engineering tracheal stent has the advantages of achieving complete simulation, and keeping the tracheal flexibility as well as the sputum excretion ability, reducing occurrence rate of infection after transplanting; the tracheal stent can be applied to juvenile body; the tracheal stent can be degraded in the body and is free from toxic and harm to the body.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a 3D printed incomplete tracheal ring that can be embedded in a double-layer PLLA tissue engineering trachea stent and its application. Background technique [0002] At present, the existing tissue engineering 3D printed PLLA scaffold is a complete tracheal ring, and it is a single layer, and only tracheal chondrocytes can be planted on the surface. This kind of scaffold is a complete tracheal ring, lacking growth potential, and due to failure to plant Ciliated columnar epithelial cells, so there is no ability to expel sputum, and infection is prone to occur after transplantation, resulting in failure of tracheal transplantation. Therefore, there is an urgent need for a fully degradable, fully bionic, incomplete tracheal ring PCL tracheal stent constructed by 3D printing technology, and a tissue engineered tracheal stent that fully conforms to the physiological structure ...

Claims

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Application Information

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IPC IPC(8): A61F2/04
CPCA61F2/04A61F2002/046A61F2240/001
Inventor 高波涛郑景浩荆辉何晓敏刘玉洁罗凯
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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