Calicheamicin constructs and methods of use

An antibody, unsubstituted technology, applied in the field of novel compounds, can solve the problem that treatment methods cannot prevent recurrent tumor recurrence and metastasis, and overall survival rate remains unchanged

Inactive Publication Date: 2018-03-27
ABBVIE STEMCENTRX LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Overall survival rates for many solid tumors have remained largely unchanged over the years, at least in part due to the inability of existing treatments to prevent recurrence, tumor reappearance, and metastasis

Method used

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  • Calicheamicin constructs and methods of use
  • Calicheamicin constructs and methods of use
  • Calicheamicin constructs and methods of use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment P1

[0591] Example P1. Formula Ab-[W-(X1) a -CM-(X2) b -P-D] n An antibody drug conjugate or a pharmaceutically acceptable salt thereof, wherein a) Ab comprises a targeting agent; b) W comprises a linking group; CM comprises a cleavable moiety; d) P comprises a disulfide bond protecting group; e) X1 and X2 comprise an optional spacer moiety; and f) D comprises calicheamicin; wherein a and b are independently 0 or 1 and n is 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

Embodiment P2

[0592] Embodiment P2. The antibody drug conjugate of embodiment P1, wherein the targeting agent comprises an antibody.

[0593] Embodiment P3. The antibody drug conjugate of Embodiment P2, wherein the antibody comprises a chimeric, CDR grafted, humanized or human antibody or immunoreactive fragment thereof.

Embodiment P4

[0594] Embodiment P4. The antibody drug conjugate of embodiment P2 or P3, wherein the antibody comprises an anti-SEZ6 antibody.

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Abstract

Provided herein are antibody drug conjugates (ADCs) comprising calicheamicin and methods of using the same to treat proliferative disorders.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application No. 62 / 150,693, filed April 21, 2015, which is hereby incorporated by reference in its entirety. field of invention [0003] The present application generally relates to novel compounds comprising a calicheamicin linked to a targeting agent (also referred to herein as a calicheamicin-linker construct). The targeting agent may be an antibody thereby providing an antibody drug conjugate (ADC). ADCs are useful, for example, in the treatment, diagnosis or prevention of cancer and any recurrence or metastasis thereof. Background technique [0004] Differentiation and proliferation of stem and progenitor cells are normal ongoing processes that consistently support tissue growth during organogenesis, cell repair, and cell replacement. The system is tightly regulated to ensure that only the appropriate signals are generated according to the needs of the organi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/30A61K39/44A61K39/395A61K47/68A61K31/704
CPCC07K16/30A61K2039/505A61K47/6889A61K47/6851A61K47/6809A61P35/00
Inventor J.贾夫里尔于克V.N.西索迪亚
Owner ABBVIE STEMCENTRX LLC
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