Method for removing sodium chloride in tapioca starch polysaccharide iron complex liquid

Abstract

A method for removing sodium chloride in cassava starch polysaccharide iron complex liquid, the steps are as follows: A, add tapioca starch and water in the reaction kettle, heat and adjust the pH value, add hydrogen peroxide solution to degrade the cassava starch, and obtain heavy Average molecular weight is the oligosaccharide solution of 3K-27KDa, then add ferric chloride solution and alkali and carry out complexation reaction, obtain tapioca starch polysaccharide iron liquid; B, the tapioca starch polysaccharide iron liquid that step A makes is carried out ultrafiltration, A small molecular tapioca starch polysaccharide iron complex with a molecular weight cut-off of 2.5K-200KDa, removing part of the sodium chloride, C, performing nanofiltration on the permeate from step B, and the small molecular tapioca polysaccharide with a molecular weight cut-off of nanofiltration membrane of 200 Da Iron complex, remove sodium chloride, D, combine the intercepted liquid of step B and step C, and spray dry to obtain solid tapioca starch polysaccharide iron complex, and the nanofiltration permeate can be directly discharged. The invention has the advantages of simple process, energy saving and environmental protection, mild conditions and easy continuous production; it can reduce the concentration of sodium chloride in the cassava starch polysaccharide iron complex liquid; the recovery rate of the cassava starch polysaccharide iron complex is greater than 99%, and the removal rate of sodium chloride is greater than 99%. 98%.

Description

technical field [0001] The invention relates to a method for removing sodium chloride in cassava starch polysaccharide-iron complex liquid, in particular to a method for removing sodium chloride in cassava starch polysaccharide-iron complex liquid by applying ultrafiltration and nanofiltration membrane combination technology Sodium chloride and the method of concentration. Background technique [0002] As an iron supplement, the polysaccharide-iron complex has good stability and is less irritating to the stomach. The polysaccharide itself has various biological activities and is easy to be absorbed and utilized by humans and animals. It has a significant effect on treating iron deficiency anemia in humans and animals. Certain iron polysaccharides such as iron dextran have been widely used clinically. The polysaccharide-iron complex is composed of sugar base and glycoside iron. The sugar base can be dextran (dextran), tapioca starch sugar, chitosan, sucrose, plant polysaccha...

AI Technical Summary

Problems solved by technology

Polysaccharide-iron complex is actually a general term for high-molecular-weight polysaccharide-iron complexes with a wide range of molecular weight distribution. It is prepared by reacting polysaccharides and ferric chloride. The prepared polysaccharide-iron complex synthesis reaction completion solution contains A large amount of sodium chloride (10~20%wt), if directly concentrated and dried to produce polysaccharide iron dry product, because it contains a large amount of sodium chloride does not meet the requirements for use, especially not suitable for the preparation of injections, and sodium chloride is easy to Moisture absorption makes the product easy to agglomerate, which is not conducive to preservation. Therefore, the sodium chloride in the polysaccharide-iron complex must be removed

[0003] In the traditional process, alcohols such as ethanol can be used as precipitant to separate sodium chloride in polysaccharide iron complex. The operation process of this method is relatively complicated, and ethanol is a flammable and explosive substance, which has potential safety hazards in production, and the recovery of ethanol requires a large amount of of steam, the production cost is higher

[0004] Chinese patent CN101585887 discloses a method for desalting and concentrating an aqueous solution of iron dextran complexes using nanofiltration technology. The method first uses microfiltration membranes for pretreatment and then concentrates them with nanofiltration membranes. The patented method is aimed at The method of removing sodium chloride and concentrating the iron dextran reaction within the scope of the stock solution is to use tapioca starch as raw material, and tapioca starch polysaccharide iron obtained by hydrogen oxidation degradation and ferric chloride reaction It is not suitable to remove sodium chloride and concentrate the complex reaction completion liquid. There are two main reasons: 1. The molecular weight distribution of cassava starch polysaccharide degraded by hydrogen peroxide is very wide. According to different degradation processes, the molecular weight distribution ranges from several thousand to Hundreds of thousands; 2. The pore size of the microfiltration membrane is generally 0.1-1 μm, which can only intercept particles with a particle size larger than 0.1 μm in the solution, and remove impurities brought by cassava starch polysaccharide-iron complex molecules and tapioca starch raw materials Such as vegetable protein, etc. cannot be intercepted

The combination technology of ultrafiltration and nanofiltration proposed by the present invention can solve the above-mentioned problems preferably, and use cassava starch as raw material, the cassava starch polysaccharide obtained through acid degradation and iron trichloride reaction synthesis cassava starch polysaccharide iron composite Removal of sodium chloride and concentration of the reaction completed liquid has good effects, simple and safe operation process, energy saving and environmental protection, mild conditions, and easy continuous production. The recovery rate of cassava starch polysaccharide iron complex is greater than 99%, and the removal rate of sodium chloride is greater than 98%. , the nanofiltration permeate can be discharged directly, there is no similar report at home and abroad

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