Aggregation induced luminescent probe, preparation and application thereof in calcium ion detection and imaging
A technology of aggregation-induced luminescence and probe, which is applied in the field of calcium ion detection, can solve the problems of cumbersome operation, fluorescence self-quenching, low signal-to-noise ratio, etc., and achieve the effect of good solubility and low cytotoxicity
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[0076] (1) Synthesis of formula IV-1 compound, its synthetic equation is as follows::
[0077]
[0078] 5-benzylchlorosalicylaldehyde (340mg, 2mmol), diethyl iminodiacetate (378mg, 2mmol), N,N-diisopropylethylamine (i-Pr 2 EtN) (330 μL, 258 mg, 2.0 mmol) was refluxed in acetonitrile (10 mL) for 2 hours. After the reaction was completed, it was cooled to room temperature, the solvent was evaporated under reduced pressure, and the residue was separated by silica gel column chromatography (petroleum ether: ethyl acetate = 5:1) to obtain the compound of formula IV-1 (288mg, 89%). 1 H NMR (CDCl 3 ,500MHz)δ10.79(s,1H),9.72(s,1H),7.48(d,J=2.0Hz,1H),7.43(dd,J 1 =8.5Hz,J 2 =2.0Hz,1H),6.77(d,J=8.5Hz,1H),4.01(q,J=7.5Hz,4H),3.74(s,2H),3.39(s,4H),1.11(t,J =7.5Hz,6H); 13 C NMR (CDCl 3 ,125MHz)δ196.5,170.9,160.9,137.8,133.9,129.9,120.3,117.5,60.4,56.5,54.0,14.1.
[0079] (2) Synthesis of formula III-1 compound, its synthetic equation is as follows:
[0080]
[0081] Dissolve th...
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