Application of RDH10 gene to brain glioma diseases

A technology of RDH10 and glioma, which is applied in the research field of the pathogenesis of glioma, can solve the problems such as no application report of RDH10 gene, unknown biological function and clinical significance of RDH10 gene, etc.

Active Publication Date: 2018-02-27
BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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Problems solved by technology

The biological function and clinical significance of RDH10 gene in glioma are still unknown, so far th

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  • Application of RDH10 gene to brain glioma diseases
  • Application of RDH10 gene to brain glioma diseases
  • Application of RDH10 gene to brain glioma diseases

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[0027] Below in conjunction with specific embodiment, further illustrate the present invention. It should be understood that these examples are only used to illustrate the present invention and not to limit the scope of the present invention. In addition, it should be understood that after reading the content taught by the present invention, those skilled in the art can make various changes or modifications to the present invention, and these equivalent forms also fall within the scope defined by the appended claims of the present application.

[0028] Materials and methods

[0029] Glioma specimen collection and RDH10 immunohistochemical analysis

[0030] 150 samples of glioma were used for research, and this study was approved by the Ethics Committee of Beijing Tiantan Hospital Affiliated to Capital Medical University; among the 150 samples, the number of samples of different glioma grades was similar. We stained, formalin-fixed, paraffin-embedded tissues using the IHC met...

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Abstract

The invention discloses application of RDH10 gene to brain glioma diseases. The RDH10 gene is highly expressed in brain gliomas, and the RDH10 gene is closely related to the brain glioma grade and thesurvival time of a patient. In-vitro lentivirus-mediated shRNA RDH10 gene knockout significantly inhibits proliferation and apoptosis of glioma cells, increases and induces S-G2/M cell cycle arrest and inhibits the invasion functions of the glioma cells. RDH10 gene knockout also slows growth of neurogliomas of a nude mouse. Researches find that both in vivo and in vitro, the RDH10 gene plays an important role in occurrence and progression processes of the brain gliomas, and according to high expression results of the RDH10 gene in brain glioma tissues, a powerful method is provide for biological targeted treatment to the gliomas in the further.

Description

technical field [0001] The present invention relates to the research field of glioma pathogenesis, in particular to an application of RDH10 gene in glioma disease. Background technique [0002] Glioma is the deadliest type of human brain malignancy, and there is still no effective treatment. Epidemiological data show that glioma accounts for 32%-45% of primary brain tumors and nearly 70%-80% of malignant brain tumors. In addition, the survival time of nearly 95% of glioma patients is less than 5 years, and the 5-year survival period of glioblastoma is even less than 5%. Although some achievements have been made in surgical treatment, radiation therapy and chemotherapy for glioma, the treatment of glioma is still a challenge in clinical oncology. In order to obtain the desired therapeutic effect, researchers conducted in-depth studies on the underlying molecular mechanisms and genetics of human glioma. Although the genomic map of human glioma has been revealed, the mysteri...

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158
Inventor 张俊廷关峰王亮康庄
Owner BEIJING TIANTAN HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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