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Combined medicine for treating non-small cell lung cancer

A non-small cell lung cancer and drug technology, applied in the field of medicine, can solve problems such as cancer treatment that has not yet been seen, achieve significant effects, reduce drug resistance, and increase efficacy

Active Publication Date: 2018-02-16
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no report on the combination of Periplaneta americana and gefitinib for cancer treatment

Method used

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  • Combined medicine for treating non-small cell lung cancer
  • Combined medicine for treating non-small cell lung cancer
  • Combined medicine for treating non-small cell lung cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 American cockroach extract

[0024] Weigh Periplaneta americana, pulverize, add 80% ethanol that is 12 times the weight of the original medicinal material, reflux and extract 3 times at 80°C for 1 hour, filter, and concentrate the filtrate under reduced pressure until the specific gravity is 1.10~1.20 (60~65 ℃), add pure water 12 times the weight of the concentrated solution to the concentrated solution, stir at 75 ℃ for 20 minutes, refrigerate and let it stand, absorb the upper layer of grease with filter paper, filter the lower layer, then concentrate under reduced pressure, dry, and pulverize. It is the extract of Periplaneta americana.

Embodiment 2

[0025] The preparation of embodiment 2 Periplaneta americana medicinal powder

[0026] Place the adult Periplaneta americana in a vacuum desiccator and dry at 45°C until the water content is 2% to obtain dried adult Periplaneta americana; place the adult Periplaneta americana at a temperature set at -150°C Pulverize to 200 mesh in an ultra-low temperature pulverizer to obtain the Periplaneta americana medicinal powder.

Embodiment 3

[0028] The combined drug of Periplaneta americana and gefitinib comprises: 4500 mg of the extract of Periplaneta americana described in Example 1 and 233 mg of gefitinib in parts by weight.

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PUM

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Abstract

The invention provides a combined medicine for treating non-small cell lung cancer. The medicine contains the active ingredients including american cockroach and gefitinib, wherein american cockroachadopts american cockroach extract or american cockroach medicinal powder, and the weight ratio of the active ingredients of the medicine, namely, the american cockroach extract to gefitinib is (4200-5000): 233, preferably, american cockroach extract to gefitinib is 4500 to 233; american cockroach medicinal powder to gefitinib is (2300-3200): 233, preferably, american cockroach medicinal powder togefitinib is 3000 to 233. The medicine has an obvious effect in treating cancer, especially has an obvious effect when taken as the medicine for treating non-small cell lung cancer, the obvious synergistic effect is achieved after american cockroach and gefitinib are combined for use, the efficiency is higher than that obtained by independently using gefitinib or american cockroach, meanwhile, thedrug tolerance generated when gefitinib or american cockroach is independently used can be reduced, and thus the effect of the medicine in treating cancer is guaranteed.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to a combination medicine for treating non-small cell lung cancer. Background technique [0002] Lung cancer is a common clinical malignant tumor. Among many cancers, lung cancer ranks first in the global cancer mortality rate. Non-small cell lung cancer (NSCLC) accounts for 80% of lung cancer. Lung cancer is one of the first types of cancer to use targeted therapy in the clinic. Small molecule compound tyrosine kinase inhibitors are widely used in clinical targeted therapy of NSCLC patients, and their target is epidermal growth factor receptor (Epidermal Growth Factor Receptor, EGFR). [0003] Gefitinib (Gefitinib), the chemical name is 4-(3-chloro-4-fluoroaniline)-7-methoxy-6-(3-isopropyleneoxy)quinazoline, which is a synthetic aniline A quinazoline compound is a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor. It is suitable for the third-line, second-line o...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P35/00A61K31/5377
CPCA61K31/5377A61K35/63A61K2300/00
Inventor 耿福能林庆华沈咏梅
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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