Marker for forecasting nasopharynx cancer transfer risk and application thereof
A marker, nasopharyngeal cancer technology, applied in recombinant DNA technology, microbial determination/examination, biochemical equipment and methods, etc. Accurately predicted performance
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[0021] The technical solution of the present invention will be further described below in combination with experiments.
[0022] Case screening:
[0023] The inventor selected 937 patients as samples of patients with non-metastatic locally advanced nasopharyngeal carcinoma, all of whom received radical radiotherapy. Among them, 56.6% of the patients (530 cases) also received concurrent chemotherapy based on cisplatin. After 68.1 months (quartile IQR 44.6 ~ 84.4), 209 of them had metastases during the follow-up period.
[0024] The inventors used the Affymetrix Human Gene 2.0ST expression profile chip to detect 24 cases of high risk of metastasis (no metastasis at first diagnosis, but distant metastasis occurred within 2 years after radical treatment) and 24 cases of low risk of metastasis (no metastasis at first diagnosis, and radical treatment). 137 differentially expressed genes were obtained by screening the first-diagnosed biopsy paraffin tissue specimens of nasopharynge...
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