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rs7901016 detection system related to blood lipid level and coronary heart disease and related applications

A level and blood technology, applied in the rs7901016 detection system and related application fields related to blood lipid level and coronary heart disease, can solve the problem of lack of research data in Asian populations

Active Publication Date: 2021-10-15
FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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Problems solved by technology

However, almost all of these loci were originally identified in populations of European ancestry, and data from studies in Asian populations, especially Chinese populations, are lacking

Method used

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  • rs7901016 detection system related to blood lipid level and coronary heart disease and related applications
  • rs7901016 detection system related to blood lipid level and coronary heart disease and related applications
  • rs7901016 detection system related to blood lipid level and coronary heart disease and related applications

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Embodiment 1

[0024] The invention is divided into two stages (preliminary screening stage and verification stage) to respectively detect and analyze the genetic variation related to the genetic variation and TC, LDL-C, HDL-C and TG.

[0025] The study population was East Asian population, including 44,985 subjects in the first phase and 13,408 subjects in the validation phase. Each study was approved by the ethics committee of its research institution and the local investigating institution. All participants signed informed consent in writing.

[0026]In the first stage, a meta-analysis of exome association studies was conducted on 44,985 survey subjects in the East Asian population. 44,985 subjects, from China Eye Study (CHES), China Health and Nutrition Survey (CHNS), Fangchenggang Male Health Examination Survey (FAMHES), Guizhou Bijie Type 2 Diabetes Study (GBTDS), Hong Kong University Special Research Program (HKU-TRS) ), Hubei Coronary Heart Disease Study (HuCAD) and Chinese Aging P...

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Abstract

The present invention provides a rs7901016 detection system related to blood lipid levels and coronary heart disease and its application; specifically, the present invention determines that the single nucleotide polymorphism rs7901016 is related to blood lipid levels, and provides a method for detecting samples from individuals to be tested The application of the polymorphism reagent material and / or instrument of the rs7901016 site in the preparation of a detection system for assessing blood lipid levels, dyslipidemia and / or coronary heart disease risk also provides a method for assessing blood lipid levels, blood lipid A detection system for abnormality and / or risk of coronary heart disease, which includes: reagent materials and / or equipment for detecting the polymorphism of the rs7901016 site in a sample from an individual to be tested; wherein, rs7901016 is significantly correlated with LDL-C levels, Carriers of the T allele at rs7901016 have higher LDL-C levels and / or higher risk of coronary heart disease than non-carriers.

Description

technical field [0001] The present invention relates to a single nucleotide polymorphism rs7901016 detection system related to blood lipid levels and coronary heart disease and related applications, in particular, the present invention relates to a reagent for detecting the polymorphism of the CD16 gene rs7901016 site in a sample from an individual to be tested Application of materials and / or instruments and equipment in the preparation of a detection system for evaluating blood lipid levels, abnormal blood lipids and / or risk of coronary heart disease, and also relates to a detection system for evaluating blood lipid levels, abnormal blood lipids and / or risk of coronary heart disease . Background technique [0002] A large number of research data show that dyslipidemia is an independent risk factor for coronary heart disease, myocardial infarction, sudden cardiac death and ischemic stroke. It causes hidden, gradual, progressive, systemic and organic damage to the body by ac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883
CPCC12Q1/6883C12Q2600/156C12Q2600/172
Inventor 鲁向锋顾东风黄建凤陈恕凤李建新
Owner FUWAI HOSPITAL CHINESE ACAD OF MEDICAL SCI & PEKING UNION MEDICAL COLLEGE
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