Plant extract for treating breast invasive ductal carcinoma and preparation method thereof

A technology of extracts and drugs, applied in the field of seabuckthorn extract and its preparation, can solve the problems of lack of treatment methods and large limitations, and achieve the effect of high extraction efficiency, safe and easy operation

Inactive Publication Date: 2018-01-09
广东瑞普生物科技有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0014] Existing methods for the treatment of invasive ductal carcinoma of the breast have large limitations, and there is a lack of simple and effective treatment methods

Method used

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  • Plant extract for treating breast invasive ductal carcinoma and preparation method thereof
  • Plant extract for treating breast invasive ductal carcinoma and preparation method thereof
  • Plant extract for treating breast invasive ductal carcinoma and preparation method thereof

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preparation example Construction

[0052] Preparation of seabuckthorn extract:

[0053] 1) Dry the seabuckthorn at 55-65°C and crush it to 80-120 mesh, add 5-15 times of water, and stir and extract at 45-55°C for 4 hours;

[0054] 2) Remove insoluble matter, use a 0.45 μm filter membrane for primary filtration, and then use a 0.22 μm filter membrane for secondary filtration, collect the obtained filtrate and freeze-dry to obtain the seabuckthorn extract.

[0055] The above-mentioned seabuckthorn extract was taken for detection, and the detection results were as follows: Figure 1~3 shown. in, figure 1 It is the absorbance curve of the seabuckthorn extract aqueous solution (300mg / mL) at a wavelength of 200nm to 600nm, showing that it has a peak at 272nm, and its absorbance reaches 0.981; figure 2 is the liquid chromatogram of seabuckthorn extract; image 3 is another liquid chromatogram of seabuckthorn extract and the mass spectrum of its main peak.

[0056] After testing, every 1000g of seabuckthorn extra...

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Abstract

The invention discloses plant extract for treating breast invasive ductal carcinoma and a preparation method thereof. After many years of researches, the inventor finds out and confirms that fructus hippophae extract can be used for locking and selectively treating the breast invasive ductal carcinoma for the first time, and the effective rate of the fructus hippophae extract on the breast invasive ductal carcinoma reaches 99.8 percent to 99.9 percent, so that the fructus hippophae extract hopefully becomes a medicine which has an extremely great attraction force and is used for treating the breast invasive ductal carcinoma. A possible acting mechanism is that the effect of resisting the breast invasive ductal carcinoma is realized through inhibiting cell proliferation, inducing cell apoptosis and inhibiting angiogenesis. The plant extract disclosed by the invention has a relatively strong targeting ability on the treatment of the breast invasive ductal carcinoma, does not have the drug resistance and has no crossed drug resistance with a traditional chemotherapeutic drug. The fructus hippophae extract is safe and has no toxin, and hopefully becomes a novel plant medicine which isused for treating the breast invasive ductal carcinoma.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a plant extract and its preparation method and application, in particular to seabuckthorn extract and its preparation method and application. Background technique [0002] As we all know, malignant tumor is a kind of frequently-occurring and common disease that seriously threatens human health. Together with viral diseases and senile diseases, it is called the three major challenges of modern medicine. Its pathogenesis has not been fully elucidated, and the treatment effect is not satisfactory. According to incomplete statistics, the global average annual R&D and treatment expenses for tumors are tens of billions, which brings huge losses to the country, society and individuals. [0003] A new survey shows that breast cancer in cities such as Shanghai, Beijing and Guangzhou has become the most threatening malignant tumor to women. The incidence rate has grown from 17 / 100,000 in 1972 to 5...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P35/00
Inventor 谢丹
Owner 广东瑞普生物科技有限公司
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