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Flow Cytometry Based on Microfluidic Technology and Linear Array Detector

A linear array detector and microfluidic technology, applied in the field of flow cytometry, can solve the problem of low resolution of cell images, and achieve the effects of good acquisition effect, reduction of the amount of acquired data, and favorable cell flow counting.

Active Publication Date: 2020-03-31
XIAN UNIV OF TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The purpose of the present invention is to provide a flow cytometer based on microfluidic technology and linear array detectors, which solves the problem of extremely low resolution of cell images collected by existing flow cytometers

Method used

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  • Flow Cytometry Based on Microfluidic Technology and Linear Array Detector
  • Flow Cytometry Based on Microfluidic Technology and Linear Array Detector
  • Flow Cytometry Based on Microfluidic Technology and Linear Array Detector

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Embodiment Construction

[0029] The present invention will be described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0030] The present invention is based on the flow cytometer of microfluidic technology and linear array detector, such as figure 1 As shown, it includes a microfluidic chip 1 connected in sequence, a linear array detector 2 and a data processing device 3; wherein, the data processing device 3 has two structures: the first structure, such as figure 2 As shown, the data processing device 3 is a host computer PC14 provided with a data interface; the second structure, such as image 3 As shown, the data processing device 3 includes a data transmission module 4 and a data processing module 13 connected together.

[0031] Data processing module 13 has three kinds of structures, respectively as follows:

[0032] The first structure, such as Figure 4 As shown, the ASIC chip 15 is set in the data processing module 13;

[0033] The second structu...

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Abstract

The invention discloses a flow cytometry instrument based on a micro-fluidic technology and a linear array detector. The instrument includes, in a successively connected manner, a micro-fluidic chip, a linear array detector and a data processing apparatus, and includes a light source which is located right above the micro-fluidic chip. A linear main channel is formed inside the micro-fluidic chip, wherein one end of the main channel is provided with a sample inlet while the other end is provided with a sample outlet. The lower surface of the micro-fluidic chip is adhered to the upper surface of the linear array detector. An included angle theta is formed between the main channel and the linear array detector, 0 degree <= theta <= 90 degrees. The flow cytometry instrument mainly combines the cell movement in multiple micro-fluidic channels in the micro-fluidic chip and scanning imaging of a traditional linear array detector, so that compared with a flow cytometry instrument based on an area array detector and the micro-fluidic technology, the flow cytometry instrument can form a cell image in higher resolution ratio, and is more accurate and has higher speed in cell flowing counting.

Description

technical field [0001] The invention belongs to the technical field of cell detection devices, and relates to a flow cytometer based on microfluidic technology and linear array detectors. Background technique [0002] Cell detection plays an important role in medical research and detection of many diseases. However, the existing medical detection systems all have defects such as bulky, complicated detection process and long period. Microfluidic technology can integrate basic operations such as sample preparation, separation, reaction and detection in the chemical and biological fields on a chip of a few square centimeters. This kind of microfluidic chip is small, easy to use, and has the characteristics of micro-quantization of detection samples, fast analysis speed, low power consumption and automation, which makes it show a unique development prospect in the application of medical research. [0003] The combination of microfluidic technology into the cell detection syste...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N15/14
CPCG01N15/1434
Inventor 余宁梅方元王伍娟路伟刘仪
Owner XIAN UNIV OF TECH
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