Trinuclear rare earth complex based on schiff base ligand as well as solvent thermal preparation method and application of trinuclear rare earth complex

Abstract

The invention provides a trinuclear rare earth complex based on a schiff base ligand as well as a solvent thermal preparation method and application of the trinuclear rare earth complex. Schiff base formed by 4-aminoantipyrine and aromatic aldehyde with one hydroxyl group respectively at an ortho-position and a meta-position is taken as the ligand; the schiff base ligand is enabled to react with rare earth metal ions for 48-72h in a closed way under the conditions of low temperature and a mixed organic solvent, and is then subjected to coordination in a closed high pressure environment, so that the trinuclear rare earth complex which is clear in structure and stable in properties can be formed; from the view of the structure of the complex, the two hydroxyl oxygen adjacent atoms, which are respectively positioned at the ortho-position and the meta-position of the aromatic aldehyde, not only participate in the coordination, but also form an oxygen bridge so as to link three rare earth metal ions, so that the stability of the complex is improved. The solvent thermal preparation method of the trinuclear rare earth complex is simple and easy to control and convenient in purification, can be used for rapidly obtaining complex crystal, and facilitates structural analysis and performance study; furthermore, antibacterial experiments prove that the trinuclear rare earth complex based on the schiff base ligand has candida species resistance, thus being applied to inhibition of candida species as a bacteriostatic agent.

Description

technical field [0001] The invention relates to the field of metal complexes, in particular to a trinuclear rare earth complex based on a Schiff base ligand and a solvothermal preparation method and application thereof. Background technique [0002] 4-Aminoantipyridine is a widely used pharmaceutical intermediate. 4-Aminoantipyridine derivatives have good antibacterial and antitumor activities, so the synthesis and research of 4-aminoantipyridine derivatives It has always been a research hotspot for scientists. Schiff base mainly refers to a class of organic compounds containing imine or methylimine characteristic group (-RC=N-), which is usually formed by condensation of ammonia and active carbonyl, and has unique biological activity. 4-Aminoantipyridine has good biological properties and coordination properties, and can react with some aromatic aldehydes to form Schiff bases with C=N double bonds by condensation of aldehydes and ammonia. Such Schiff base ligands have pote...

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Problems solved by technology

[0003] However, most of the current studies are on the coordination of Schiff bases and transition metal ions. The yields of complexes formed by Schiff bases and rare earth metal ions are generally low, and the synthesis methods of the complexes are complicated, and the known Schiff bases Most of the complexes formed by the alkali and rare earth metal ions are mononuclear or dinuclear complexes, and due to the low yield, it is difficult to purify, which makes it difficult to analyze the structure of the complexes in detail.

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