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Composition containing perilla extract and gromwell root extract and application thereof

A technology of perilla extract and comfrey extract, applied in the field of plant extraction, can solve the problems of skin aging, DNA oxidative damage protein expression, elevated lipid peroxidation level, etc.

Inactive Publication Date: 2017-12-08
SHANGHAI JAHWA UNITED
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Under normal circumstances, the oxidation and anti-oxidation of the body are in a dynamic balance. Some harmful factors, such as certain exogenous compounds, UV radiation or damage to the body's own antioxidant defense system, can cause the body's The level of free radicals increases significantly, and the oxidation and anti-oxidation imbalance of the body causes the ROS content of the tissue cells in the body to increase relatively, exceeding the ability of the body to remove it, thus causing the lipid peroxidation level of the body tissue to increase, resulting in Oxidative damage to DNA and abnormal expression of proteins cause damage to the body and cause skin aging

Method used

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  • Composition containing perilla extract and gromwell root extract and application thereof
  • Composition containing perilla extract and gromwell root extract and application thereof
  • Composition containing perilla extract and gromwell root extract and application thereof

Examples

Experimental program
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Effect test

specific Embodiment approach

[0042] The inventors of the present invention unexpectedly found that the composition comprising perilla extract and comfrey extract has the effect of inhibiting tyrosinase, and can be added to external skin preparations, especially cosmetics, as an additive with whitening effect, for Skin whitening. In addition, the inventors of the present invention unexpectedly found that the composition comprising perilla extract and comfrey extract has DPPH free radical scavenging effect, and can be added to external skin preparations, especially cosmetics, as an additive with anti-aging effect, For skin anti-aging.

[0043] None of the literature mentions that the combination of perilla extract and comfrey extract has skin whitening effect, nor does it mention that it is added to cosmetics as an additive with whitening function. Similarly, none of the literature relates to the anti-aging effect of the combination of perilla extract and comfrey extract on the skin, nor does it mention ad...

Embodiment 1

[0047] Embodiment 1: the preparation of perilla extract

[0048] Take 100g of perilla leaf medicinal material, pour it into a rotary bottle, add 1000mL of 90% ethanol, extract in a 65°C water bath for 2h, filter the extract with gauze, add 1000mL of 90% ethanol to the residue, extract in a 65°C water bath for 2h, and filter through gauze , combined the secondary ethanol extracts, and discarded the dregs. Filter the alcohol extract with qualitative filter paper, recover ethanol under reduced pressure until it has no alcohol smell, continue to concentrate to 100g, and obtain an extract with a crude drug concentration of 1g / g, and obtain perilla extract for future use.

Embodiment 2

[0049] Example 2 Preparation of Comfrey Extract

[0050] Take 100g of comfrey medicinal material, pour it into a rotary bottle, add 1000mL of 90% ethanol, extract in a 65°C water bath for 2h, filter the extract with gauze, add 1000mL of 90% ethanol to the residue, extract in a 65°C water bath for 2h, filter through gauze, The second ethanol extracts were combined, and the dregs were discarded. Filter the alcohol extract with qualitative filter paper, recover ethanol under reduced pressure until there is no alcohol smell, continue to concentrate to 100g, and obtain an extract with a crude drug concentration of 1g / g, and obtain a comfrey extract for future use.

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Abstract

The invention discloses a composition containing a perilla extract and a gromwell root extract. The composition is prepared through the following methods that (a), perilla is extracted through ethanol and filtered, a filtrate is decompressed and condensed, and thus the perilla extract is obtained; (b), gromwell root is extracted through ethanol and filtered, a filtrate is decompressed and condensed, and thus the gromwell root extract is obtained; and (c) the perilla extract prepared in the step (a) and the gromwell root extract prepared in the step (b) are combined, and then the composition containing the perilla extract and the gromwell root extract is obtained. The invention further discloses application of the composition containing the perilla extract and the gromwell root extract in the whitening and anti-aging aspects.

Description

technical field [0001] The invention relates to the field of plant extraction, in particular to the whitening and anti-aging effects of perilla and comfrey extracts and their application in skin external preparations. Background technique [0002] Anti-aging and whitening, as important research topics in the fields of cosmetics, food, health care products, etc., have received widespread attention, and the research on anti-aging and whitening is also deepening day by day. There are more than ten kinds of theories about the mechanism of skin aging. In recent years, the most common mechanism of skin aging is free radical theory, gene theory, mitochondrial DNA damage theory and so on. At present, the mechanism of whitening is mainly to reduce the synthesis of melanin by inhibiting the activity of tyrosinase, so as to achieve the effect of whitening. [0003] Free radicals, also known as active oxygen, are most closely related to skin aging. They are produced by the body during...

Claims

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Application Information

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IPC IPC(8): A61K8/9789A61Q19/02A61Q19/08A61K36/535A61P17/00A61P17/18A23L33/105
Inventor 冯冰陆泽安王帅马来记
Owner SHANGHAI JAHWA UNITED
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