Application of pancreatic GnRH receptor function regulator to preparation of drugs used for treating type 2 diabetes

A technology of modulators and modulators, applied in drug combinations, metabolic diseases, pharmaceutical formulations, etc., can solve the problems of not covering the phase of insulin hormone, not involved, etc.

Inactive Publication Date: 2017-12-01
FOURTH MILITARY MEDICAL UNIVERSITY
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Problems solved by technology

[0006] However, these drugs do not involve the GnRH (gonadotropin-releasing hormone, Gonadotropin-releasing hormone) pathway involved in this application to regulate the pulse phase of insulin secretion, that is, they do not cover pancreatic islets that mainly include insulin and glucagon. The timing of hormone secretion is not related to the disorder of high glucose's inhibitory mechanism of glucagon

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  • Application of pancreatic GnRH receptor function regulator to preparation of drugs used for treating type 2 diabetes
  • Application of pancreatic GnRH receptor function regulator to preparation of drugs used for treating type 2 diabetes
  • Application of pancreatic GnRH receptor function regulator to preparation of drugs used for treating type 2 diabetes

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Embodiment Construction

[0024] The pancreatic GnRH receptor function modulator of the present invention refers to substances that affect the function of pancreatic GnRH receptors (gonadotropin-releasing hormone receptors distributed in the pancreas), which include: pancreatic GnRH receptor blockers, pancreatic GnRH receptor Agonists etc.

[0025] The pancreatic GnRH secretion regulator of the present invention implements substances that affect pancreatic GnRH secretion.

[0026] The inventor's previous research results found that the pancreas produces GnRH, and the glucagon cells of the pancreas have its receptors. It is speculated that pancreatic GnRH may regulate the secretion of glucagon, but the secretion regulation mechanism of islet hormones including glucagon is very complicated , the specific adjustment mode cannot be reasoned and predicted by those skilled in the art.

[0027] On this basis, the inventors observed that the peak of insulin secretion was delayed and increased by infusing the ...

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Abstract

The invention relates to application of a pancreatic GnRH receptor function regulator to preparation of drugs used for treating type 2 diabetes. According to the invention, pancreases with normal glucose concentration and pancreases with high-concentration glucose for simulating diabetes are subjected to perfusion of GnRH and a pancreatic GnRH receptor, and results show that pancreatic GnRH with a certain concentration has important regulating effect on the secretion time phase of main hormones of pancreatic islets, i.e., insulin and pancreatic glucagon and that a perfusion solution with certain-concentration GnRH does not inhibit the secretion of pancreatic glucagon, stimulates the secretion of pancreatic glucagon instead and leads to delay of the secretion peak of insulin. Thus, a theoretical and experimental foundation is provided for preparation of drugs for regulating the secretion time phase of insular hormones in virtue of pancreatic GnRH and regulating substances for the receptor approach of pancreatic GnRH and further for preparation of drugs used for restoring inhibition of high glucose on pancreatic glucagon in virtue of pancreatic GnRH and the receptor approach thereof.

Description

technical field [0001] The invention relates to a medicine for treating type 2 diabetes, in particular to the application of a pancreatic GnRH receptor function regulator for preparing a medicine for treating type 2 diabetes, and the use of a pancreas GnRH secretion regulator for preparing a medicine for treating type 2 diabetes. Background technique [0002] The pathogenesis of type 2 diabetes is not completely clear, but the defect of insulin secretion is one of the important mechanisms of type 2 diabetes. [0003] Taking insulin secretion as an example, there are pulse secretion, first-phase secretion (called early-phase secretion in some specific studies) and second-phase secretion in physiological insulin secretion, all of which belong to the phase problem of insulin secretion . At the same time, a variety of islet cells in the islets interweave and interact with each other, and there is also a problem with the secretion phase; other islet hormones represented by gluca...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61P3/10
CPCA61K45/00
Inventor 姬秋和
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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