Composition comprising benzyl alcohol derivatives and other antimicrobial active compounds
A technology of composition and compound, applied in the medicine for treating Aspergillus niger, antimicrobial active compound, antimicrobial composition, synergistically enhancing the antimicrobial activity of some antimicrobial active substances, dealing with Aspergillus niger, can solve the effect of Aspergillus niger not enough
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Embodiment 1a
[0434] Example 1a: a mixture comprising 1,2-hexanediol and 1,2-octanediol (product A, not according to the invention), comprising 4-methylbenzyl alcohol (product B, not according to the invention) and comprising 1 , Comparison of Adequate Preservation of Cosmetic Preparations of a Mixture of 2-Hexanediol, 1,2-Octanediol and 4-Methylbenzyl Alcohol (Product C, According to the Invention).
[0435] Adequate preservative tests are carried out in accordance with the European Pharmacopoeia.
[0436]The test thus consists of contaminating the preparation (if possible, the preparation in its final state) with a defined inoculum of suitable microorganisms, storing the inoculated preparation at a certain temperature, removing samples from the container at certain time intervals and determining the samples thus removed. The number of microorganisms in . Preservation is adequate if, under the test conditions, there is a marked reduction or, where appropriate, no increase in the number of...
Embodiment 1b
[0461] Example 1b: a mixture comprising 1,2-hexanediol and 1,2-octanediol (product A, not according to the invention), comprising 4-methylbenzyl alcohol (product B, not according to the invention) and comprising 1 , Comparison of Adequacy of Preservation of Cosmetic Preparations of a Mixture of 2-Hexanediol, 1,2-Octanediol and 4-Methylbenzyl Alcohol (Product C, According to the Invention)
[0462] Sufficient preservation tests were carried out according to the European Pharmacopoeia as described in Example 1a.
[0463] Test bacteria:
[0464] Use the following microbial strains for adequate preservative testing:
[0465] A: Escherichia coli ATCC 8739
[0466] B: Pseudomonas aeruginosa ATCC 9027
[0467] C: Staphylococcus aureus ATCC 6538
[0468] D: Candida albicans ATCC 10231
[0469] E: Aspergillus niger ATCC 16404
[0470] In each test series, the initial bacterial counts (cfu / ml; "0 value") ranged from 230,000 to 400,000.
[0471] preparation:
[0472] For the adeq...
Embodiment 2
[0487] Example 2: Comprising 1,2-octanediol (product A, not according to the invention), comprising 4-methylbenzyl alcohol (product B, not according to the invention) and comprising 1,2-octanediol and 4-methanol Adequate preservative comparison of cosmetic preparations of mixtures of benzyl alcohols (product C according to the invention)
[0488] Sufficient preservation tests were carried out according to the European Pharmacopoeia as described in Example 1a.
[0489] Test bacteria:
[0490] Use the following microbial strains for adequate preservative testing:
[0491] A: Escherichia coli ATCC 8739
[0492] B: Pseudomonas aeruginosa ATCC 9027
[0493] C: Staphylococcus aureus ATCC 6538
[0494] D: Candida albicans ATCC 10231
[0495] E: Aspergillus niger ATCC 16404
[0496] In each test series, the initial bacterial counts (CFU / g; "0 value") ranged from 230,000 to 400,000.
[0497] preparation:
[0498] For the adequate preservation test, the defined amount of active co...
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