A kind of artificial ligament surface modification method

Abstract

The invention relates to a surface finishing method of an artificial ligament. The surface finishing method mainly comprises the following steps: (1) a deep cleaning procedure of an artificial ligament fabric, (2) a peroxidation procedure of a fiber surface, (3) a graft polymerization procedure of the fiber surface, (4) a rewashing procedure and (5) a sectional coating procedure. The surface finishing method is characterized in that by utilizing a multi-step ultrasonic / lotion cooperative treatment manner, a relatively good surface can be obtained; by utilizing an ozone / ultraviolet combined oxidation method, the grafting efficiency is beneficially improved, and the generation of homopolymers is reduced; a grafted hydrophilic polymer layer is of a three-dimensional network-shaped gellike structure, so that a relatively good environment is provided for the development of cells; by carrying out rewashing, the surface of the ligament fabric is relatively clean, and the adhesion, growth and proliferation of the cells are promoted; by sectionally coating a biochemical reagent and a mineralization coating layer, the growth of autologous synovial tissues is easily induced by a ligament joint cavity segment, and the ligament autogeny is beneficially carried out; and the osteogenic property of a bone tunnel segment is enhanced, and the healing of the ligament and bones is relatively good.

Description

technical field [0001] The invention relates to the field of biomaterials, in particular to a method for surface modification of artificial ligaments. Background technique [0002] Knee cruciate ligament injury is one of the most common knee injuries, usually caused by strenuous knee movement, if not treated in time, it will lead to knee instability and cartilage degeneration, affecting the quality of life of patients. In current cruciate ligament reconstruction treatments, artificial ligaments are increasingly used. [0003] At present, the artificial ligaments widely used in clinic mainly include LARS, Ligastic, Leeds-Keio and Neoligaments, all of which are made of polyethylene terephthalate (PET). Due to the symmetrical molecular structure of PET, high crystallinity, and no strong polar groups in the molecule, its surface affinity is poor, and it is easy to cause postoperative complications such as infection, chronic synovitis, and stiffness after implantation in the hum...

AI Technical Summary

Problems solved by technology

In addition, due to the existence of biological and mechanical factors, the fusion of the artificial ligament graft and the bone tunnel is not good, and the expansion of the bone tunnel is more common in clinical practice.

After the bone tunnel is enlarged, it needs to be repaired again, and the bone defect in the enlarged part makes the attachment and fixation of the graft more difficult, and the operation needs to be performed in stages, which significantly increases the operation cost and the pain of the patient