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Calcium phosphate biological bone cement composite material reinforced by carbon nanotube and graphene

A technology of composite materials and carbon nanotubes, which is applied in the intersecting fields of materials science and biomedicine, can solve the problems of low strength, lack of solutions, poor toughness, etc., and achieve improved strength, good strength and biocompatibility, and shortened coagulation the effect of time

Active Publication Date: 2017-11-21
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In summary, the problems of low strength and poor toughness existing in calcium phosphate bio-bone cement composite materials in the prior art still lack effective solutions

Method used

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  • Calcium phosphate biological bone cement composite material reinforced by carbon nanotube and graphene
  • Calcium phosphate biological bone cement composite material reinforced by carbon nanotube and graphene
  • Calcium phosphate biological bone cement composite material reinforced by carbon nanotube and graphene

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] The ratio of the calcium phosphate bio-bone cement composite material is (wt%): α-tricalcium phosphate 94.8%, hydroxyapatite 5%, graphene 0-1%, carbon nanotube 0%.

[0042]First, weigh a certain amount of α-tricalcium phosphate, hydroxyapatite and graphene according to the proportion, place them in a ball mill jar, mill them at 400r / min for 5 hours, and pass through a 300-mesh sieve to obtain a calcium phosphate bio-bone cement composite. Material Raw material powder. Then the raw material powder and distilled water are mixed uniformly at 0.35ml / g, and placed in an environment with a temperature of 37° C. and a humidity of 100% to condense it. This process does not require microwave treatment. After 24 hours, a fully coagulated calcium phosphate biocement composite material was obtained.

[0043] The maximum flexural strength of the calcium phosphate bio-bone cement composite material reaches 11.6±0.2MPa, see figure 1 , the highest compressive strength reaches 59.3±3....

Embodiment 2

[0045] The ratio of the calcium phosphate bio-bone cement composite material is (wt%): α-tricalcium phosphate 94.2%, hydroxyapatite 5%, graphene 0.2%, and carbon nanotube 0.2-1%.

[0046] First, weigh a certain amount of α-tricalcium phosphate, hydroxyapatite and graphene according to the proportion, place them in a ball mill jar, mill them at 400r / min for 5 hours, and pass through a 300-mesh sieve to obtain a calcium phosphate bio-bone cement composite. Material Raw material powder. Then the raw material powder and distilled water are mixed uniformly at 0.35ml / g, and placed in an environment with a temperature of 37° C. and a humidity of 100% to condense it. This process does not require microwave treatment. After 24 hours, a fully coagulated calcium phosphate biocement composite material was obtained.

[0047] The flexural strength of the calcium phosphate bio-bone cement composite material can reach 14.5±0.2MPa, see image 3 , the compressive strength can reach 86.5±2.7MP...

Embodiment 3

[0049] The ratio of the calcium phosphate bio-bone cement composite material is (wt%): α-tricalcium phosphate 94.2%, hydroxyapatite 5%, graphene 0.2%, and carbon nanotube 0.2-1%.

[0050] First, weigh a certain amount of α-tricalcium phosphate, hydroxyapatite and graphene according to the proportion, place them in a ball mill jar, mill them at 400r / min for 5 hours, and pass through a 300-mesh sieve to obtain a calcium phosphate bio-bone cement composite. Material Raw material powder. Then mix the raw material powder and distilled water evenly at 0.35ml / g, place it in an environment with a temperature of 37°C and a humidity of 100% to coagulate it. This process continues to be treated with microwaves before the final coagulation. 4h Microwave treatment for half an hour. After 24 hours, a fully coagulated calcium phosphate biocement composite material was obtained.

[0051] The flexural strength of the calcium phosphate bio-bone cement composite material can reach 17.4±0.2MPa,...

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Abstract

The invention discloses a calcium phosphate biological bone cement composite material reinforced by carbon nanotube and graphene. The calcium phosphate biological bone cement composite material is composed of the following components in parts by weight: 94.2-95 parts of alpha-tricalcium phosphate, 4.8-5.2 parts of hydroxyapatite, 0.2-1 part of graphene, and 0.2-1 part of carbon nanotube. According to the calcium phosphate biological bone cement composite material, graphene and the carbon nanotube are adopted as the reinforcing bodies of alpha-tricalcium phosphate bone cement, so that the prepared calcium phosphate biological bone cement composite material has good strength and good biocompatibility, meanwhile, after microwave treatment, the coagulation time of the calcium phosphate biological bone cement composite material can be greatly shortened, and the strength of the calcium phosphate biological bone cement composite material is further improved. The calcium phosphate biological bone cement composite material can be used for repairing and replacing human bones and treating other orthopedic diseases. The problems of low strength and poor toughness existing in the calcium phosphate biological bone cement composite material in the prior art are solved.

Description

technical field [0001] The invention belongs to the intersecting field of material science and biomedicine, in particular to a carbon nanotube and graphene-reinforced calcium phosphate bio-bone cement composite material, in particular to a kind of α-tricalcium phosphate bio-bone cement as a matrix, and graphite Calcium phosphate bone cement composite material with ene and carbon nanotube as reinforcement and its preparation method. Background technique [0002] α-Tricalcium phosphate bone cement is a kind of calcium phosphate bio-bone cement. It has excellent bioactivity and biocompatibility, and can be degraded in the human body. It is a bone implant material with broad application prospects. It is mainly composed of α-tricalcium phosphate and liquid phase. When the solid phase and liquid phase are mixed, a coagulation reaction occurs to form a material similar to porous ceramics. Compared with hard tissues (such as bones) of the human body, its Poor toughness and low stre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/08A61L27/50
CPCA61L27/08A61L27/12A61L27/50A61L2430/02
Inventor 孙康宁王颂李爱民毕见强孙晓宁
Owner SHANDONG UNIV
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